holA
168
DNA polymerase III, delta subunit, part of the clamp-loader complex and the [wiki|replisome]
locus
BSU_25560
Molecular weight
40.35 kDa
pI
6.23
function
[category|SW.3.1.1|DNA replication]
product
DNA polymerase III, delta subunit
essential
yes
ec
2.7.7.7
synonyms
holA, yqeN
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1466 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,636,096 → 2,637,139
Phenotypes of a mutant
essential [Pubmed|12682299]
The protein
Catalyzed reaction/ biological activity
required for bacteriophage SPP1 replication [Pubmed|23268446]
[wiki|Domains]
domain I: aa 1 - 143, RecA-like fold [Pubmed|23525462]
domain II: aa 144 - 214, four alpha helices [Pubmed|23525462]
domain III: aa 215 - 339, seven alpha helices [Pubmed|23525462]
Structure
[PDB|3ZH9] [Pubmed|23525462]
[AF|P54459]
[wiki|Localization]
Nucleoid (Mid-cell) [Pubmed|16479537]
Expression and Regulation
Operons
genes
[gene|CE70B471811371D454A74F67279974BF264205C2|holA]
description
[Pubmed|22383849]
References
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Time of last update: 2024-12-22 00:15:46
Author of last update: Jstuelk