sipS
168
signal peptidase I
locus
BSU_23310
Molecular weight
20.90 kDa
pI
9.72
function
protein secretion
product
signal peptidase I
essential
no
ec
3.4.21.89
synonyms
sipS
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0681 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,432,316 → 2,432,870
Phenotypes of a mutant
a ''[gene|CDC6971F39F3EEAAE912CB1402EE1BD64D5A12A0|sipS] [gene|C2EAE417DB9250B88BB0E25D4AE760BDE82EFD86|sipT]'' double mutant is not viable [Pubmed|9694797]
The protein
Catalyzed reaction/ biological activity
Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins (according to UniProt)
intra-membrane cleavage and thus inactivation of [protein|ED1DDA187692683D9862EC0E858B80CD56C48045|rsiV] between A66 and M67 [Pubmed|25275625]
Protein family
[wiki|peptidase S26 family] (according to UniProt)
Structure
[PDB|4NV4] (from ''Bacillus anthracis'', 40% identity)
[AF|P28628]
Paralogous protein(s)
[protein|9824F9CF9C2028AF267AC43FE7FD8590E8231AB8|sipU], [protein|ADEEA5E15C100C1DC6E129B9A3E6DECAFCA8C409|sipV], [protein|C2EAE417DB9250B88BB0E25D4AE760BDE82EFD86|sipT]
[wiki|Localization]
cell membrane (according to UniProt)
Expression and Regulation
Operons
genes
[gene|9756DD153F0FAACB5A64B363D580AA8A9AE7FD58|ypzJ]-[gene|CDC6971F39F3EEAAE912CB1402EE1BD64D5A12A0|sipS]
description
[Pubmed|22383849]
genes
[gene|CDC6971F39F3EEAAE912CB1402EE1BD64D5A12A0|sipS]
description
[Pubmed|8951809]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|8951809], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Biological materials
Mutant
BKE23310 (Δ[gene|CDC6971F39F3EEAAE912CB1402EE1BD64D5A12A0|sipS]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE23310 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAACTGATTTCCTCCAATAA, downstream forward: _UP4_TAGGATCAAGCAGCTTCCCA
BKK23310 (Δ[gene|CDC6971F39F3EEAAE912CB1402EE1BD64D5A12A0|sipS]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK23310 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAACTGATTTCCTCCAATAA, downstream forward: _UP4_TAGGATCAAGCAGCTTCCCA
labs
[wiki|Jan Maarten van Dijl], Groningen, Netherlands
References
Reviews
Original Publications
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Time of last update: 2024-10-14 14:16:17
Author of last update: Jstuelk