reoY
168
effector protein of [protein|DA763F7C2192655C590752C2A285ADF902B11BCA|murAA] degradation by [protein|86A2F2F65290F4471D6FD03B694821C66C180D8A|clpC]-[protein|CB06A70DE7462CEB7AF5D8C28943C878DD56DE1A|clpP]
locus
BSU_22580
Molecular weight
21.22 kDa
pI
5.88
function
control of peptidoglycan biosynthesis
product
regulator of [protein|DA763F7C2192655C590752C2A285ADF902B11BCA|murAA] degradation
essential
no
synonyms
reoY, ypiB
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG5582 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,365,736 → 2,366,275
Phenotypes of a mutant
accumulation of [protein|DA763F7C2192655C590752C2A285ADF902B11BCA|murAA] due to reduced degradation by [protein|86A2F2F65290F4471D6FD03B694821C66C180D8A|clpC]-[protein|CB06A70DE7462CEB7AF5D8C28943C878DD56DE1A|clpP] [pubmed|32469310]
The protein
Protein family
UPF0302 family (single member, according to UniProt)
Structure
[PDB|3DO9] (from B. anthracis, 64% identity)
[AF|P54390]
Expression and Regulation
Operons
genes
[gene|057BFF91609C918CEE4E6FF9100A1E4959BF6715|ypiA]-[gene|CDBBCB467FE9442B3CE45CF9401C609295E1B99F|reoY]
description
[Pubmed|22383849]
genes
[gene|CDBBCB467FE9442B3CE45CF9401C609295E1B99F|reoY]
description
[Pubmed|22383849]
Biological materials
Mutant
MGNA-A408 (ypiB::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/408 NBRP B. subtilis, Japan]
BKE22580 (Δ[gene|CDBBCB467FE9442B3CE45CF9401C609295E1B99F|reoY]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE22580 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTAATTCCCTCCTCTAT, downstream forward: _UP4_TAATATGACCAGCCTTGCAG
BKK22580 (Δ[gene|CDBBCB467FE9442B3CE45CF9401C609295E1B99F|reoY]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK22580 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTAATTCCCTCCTCTAT, downstream forward: _UP4_TAATATGACCAGCCTTGCAG
References
Research papers
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Time of last update: 2025-04-12 23:46:53
Author of last update: Jstuelk