spoIISA

spoIISA
168

lethal when synthesized during vegetative growth in the absence of [protein|6C9F403D67CDC2EE66C534B0F23D973E24C9A089|spoIISB]

locus
BSU_12830
Molecular weight
28.91 kDa
pI
4.68
Protein length
248 aaSequenceBlast
Gene length
747 bpSequenceBlast
function
programmed cell death
product
toxin
essential
no
synonyms
spoIISA, ykaC
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms

This gene is a member of the following regulons

Gene
Coordinates
1,348,612 → 1,349,358
The protein
Protein family
SpoIISA toxin family (single member, according to UniProt)
[wiki|Domains]
three putative membrane-spanning segments and a cytoplasmic domain
Structure
[PDB|3O6Q] (cytoplasmic fragment of [protein|CD14C88E9976964A0D25BAA22C395A5A6951654D|spoIISA] (CSpoIISA) in complex with [protein|6C9F403D67CDC2EE66C534B0F23D973E24C9A089|spoIISB]) [Pubmed|21147767]
[AF|O34853]
[wiki|Localization]
cell membrane [Pubmed|20863891]
Expression and Regulation
Operons
genes
[gene|CD14C88E9976964A0D25BAA22C395A5A6951654D|spoIISA]-[gene|6C9F403D67CDC2EE66C534B0F23D973E24C9A089|spoIISB]
description
[Pubmed|11371520]
sigma factors
[protein|24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|sigK]: sigma factor, in [regulon|protein:24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|sigK regulon]
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[gene|CD14C88E9976964A0D25BAA22C395A5A6951654D|spoIISA]→[gene|6C9F403D67CDC2EE66C534B0F23D973E24C9A089|spoIISB]

2024-10-10 21:40:09

ghost

114

dba0540459879cc4ec595c8048a437eb0a18061d

5789610C653201DDB59376F461D88F12DF191D72

Biological materials
Mutant
MGNA-A006 (spoIISA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/6 NBRP B. subtilis, Japan]
1S123 ( ''spoIISA''::''kan''), [Pubmed|11371520], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1S123&Search=1S123 BGSC]
BKE12830 (Δ[gene|CD14C88E9976964A0D25BAA22C395A5A6951654D|spoIISA]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE12830 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATATTCGAATCCCTCACAT,  downstream forward: _UP4_ATTGAGGAGGAAGGTGAAGG
BKK12830 (Δ[gene|CD14C88E9976964A0D25BAA22C395A5A6951654D|spoIISA]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK12830 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATATTCGAATCCCTCACAT,  downstream forward: _UP4_ATTGAGGAGGAAGGTGAAGG
References
Reviews
31075979
Original Publications
18096016,11371520,21147767,25039482,20863891,26300872,27294956

CD14C88E9976964A0D25BAA22C395A5A6951654D

Page visits: 2715

Time of last update: 2024-10-12 20:45:38

Author of last update: Melvin.boenninger