qoxB

qoxB
168

cytochrome aa3 quinol oxidase (subunit I)

Locus
BSU_38160
Molecular weight
73.66 kDa
Isoelectric point
8.85
Protein length
649 aaSequenceBlast
Gene length
1950 bpSequenceBlast
Function
respiration
Product
cytochrome aa3 quinol oxidase (subunit I)
Essential
no
E.C.
1.10.3.-
Synonyms
qoxB, ipa-38d
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0843 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,915,319 → 3,917,268
Phenotypes of a mutant
inactivation of ''qoxB restores beta-lactam resistance in a sigM'' mutant PubMed
inactivation of qoxB facilitates without a wall (due to reduction of oxidative stress) PubMed
The protein
Catalyzed reaction/ biological activity
2 quinol + O2 --> 2 quinone + 2 H2O (according to UniProt)
Protein family
heme-copper respiratory oxidase family (with CtaD, according to UniProt)
Cofactors
Cu(B) PubMed
Structure
1FFT (PDB) (QoxA-QoxB-QoxC complex from E. coli, 52% identity) PubMed
P34956 (AlphaFold)
Paralogous protein(s)
CtaD
Localization
cell membrane PubMed
Additional information
the QoxA-QoxB-QoxC-QoxD cytochrome aa3 oxidase complex is sensitive to increased intracellular Mn2+ concentrations, this results in the generation of toxic reactive radicals PubMed
Expression and Regulation
Operons
Genes
qoxA-qoxB-qoxC-qoxD
Description
PubMed
Regulation
RelA dependent downregulation (Class I) during stringent response PubMed
Regulatory mechanism
stringent response: negative regulation, in stringent response
CitB: translation control, [pubmed|], in citB regulon
Additional information
the presence of an iron-responsive element bound by CitB between ''feuA and feuB'' suggests iron-dependent regulation by CitB PubMed
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qoxA→qoxD

2025-04-03 13:32:31

ghost

128

528706cf2ce16a4799a79387ef081442d5a898c0

DCA1ED001F8B0E6CA914E7163B3631C2F439B710

Biological materials
Mutant
BKE38160 (ΔqoxB::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGCAGGCTTCCTCCTTTC,  downstream forward: _UP4_ATTTCCGAATAAGGAGGCGT
BKK38160 (ΔqoxB::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGCAGGCTTCCTCCTTTC,  downstream forward: _UP4_ATTTCCGAATAAGGAGGCGT
References
Reviews
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Original Publications
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CBF2DCFFD8195304F942ECBA8596444F0AC47CC6

Page visits: 3890

Time of last update: 2025-04-07 13:13:45

Author of last update: Jstuelk