aimR
168
transcriptional antiterminator, allows expression of [gene|E32A2B695591C80F5A855F0D728CA75D613F8DB4|aimX], part of the arbitrium peptide-based communication system, phage SP beta lytic/lysogenic regulator
locus
BSU_20860
Molecular weight
45.16 kDa
pI
5.86
function
control of phage SP beta lysogeny
product
SP beta arbitrium transcription factor
essential
no
synonyms
aimR, yopK
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms
This gene is a member of the following regulons
Gene
Coordinates
2,208,994 → 2,210,154
Phenotypes of a mutant
reduced number of phage particles produced after prophage induction, this can be suppressed by inactivation of [gene|01BE35FB190DDC77BE19C013A8E0D980B132CBE1|yopN] [pubmed|34562384]
The protein
Catalyzed reaction/ biological activity
activates [gene|E32A2B695591C80F5A855F0D728CA75D613F8DB4|aimX] expression in the apo form (in the absence of [protein|20735BFECA52826F0F4D55843EEE7798F414993C|aimP]) [pubmed|34562384]
binds to the [gene|E32A2B695591C80F5A855F0D728CA75D613F8DB4|aimX] mRNA upstream region to act as antiterminator [pubmed|38177302]
Structure
Apo-form: [PDB|5XYB] ([Pubmed|30224798]), [PDB|5ZW5] ([Pubmed|30323253]), [PDB|6IPX] ([Pubmed|30421358]), [PDB|6HP3]([Pubmed|30745087]), [PDB|6JG5] ([Pubmed|31149347])
Complexed with AimP hexapeptide ([protein|20735BFECA52826F0F4D55843EEE7798F414993C|aimP]): [PDB|5Y24] ([Pubmed|30224798]), [PDB|5ZW6] ([Pubmed|30323253]), [PDB|6IM4] ([Pubmed|30421358]), [PDB|6HP5] ([Pubmed|30745087]), [PDB|6JG9] ([Pubmed|31149347])
Complexed with DNA: [PDB|6HP7] ([Pubmed|30745087]), [PDB|6JG8] ([Pubmed|31149347])
[AF|O31927]
Expression and Regulation
Operons
genes
[gene|CAE7D8E45DA7CDE99D3EA114DF7E368A0A126389|aimR]-[gene|20735BFECA52826F0F4D55843EEE7798F414993C|aimP]
description
[pubmed|22383849]
expression
repressed by [protein|7F82DED7C941BC501B6F810BF6541780AB87EDDD|mrpR]
regulatory mechanism
[protein|7F82DED7C941BC501B6F810BF6541780AB87EDDD|mrpR]: repression, in [regulon|protein:7F82DED7C941BC501B6F810BF6541780AB87EDDD|mrpR regulon]
Biological materials
Mutant
BKE20860 (Δ[gene|CAE7D8E45DA7CDE99D3EA114DF7E368A0A126389|aimR]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE20860 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTATTTCCCCTCATTTCT, downstream forward: _UP4_TAAAGGAGGTGAGACAATGA
BKK20860 (Δ[gene|CAE7D8E45DA7CDE99D3EA114DF7E368A0A126389|aimR]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK20860 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTATTTCCCCTCATTTCT, downstream forward: _UP4_TAAAGGAGGTGAGACAATGA
References
Research papers
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Time of last update: 2024-12-29 13:54:35
Author of last update: Jstuelk