dnaD

dnaD
168

initiation of chromosome replication, part of the [wiki|replisome]

locus
BSU_22350
Molecular weight
27.49 kDa
pI
7.17
Protein length
Gene length
function
[category|SW.3.1.1|DNA replication]
product
initiation of chromosome replication
essential
yes
synonyms
dnaD

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG3935 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,345,433 → 2,346,131
Phenotypes of a mutant
essential [Pubmed|12682299]
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The protein
Catalyzed reaction/ biological activity
binds a ssDNA motif in oriC [pubmed|37093985]
[protein|C9FEE07601AD28B2651EB881A1D9B34D5082237C|dnaD]-mediated untwisting of the DNA stimulates [protein|C352560155F5B2E951B5059794D7B319C1A3AF2C|nth] endonuclease activity at AP sites [Pubmed|21954439]
required for the assembly of the replicative helicase [protein|5CF09E089AA70A32F640CE0D33D1F05312AAE24D|dnaC] at the origin of replication [Pubmed|22821970]
interaction with [protein|6740108089F13116F200C15F35C2E7561E990FEB|dnaA] inhibits the ability of [protein|6740108089F13116F200C15F35C2E7561E990FEB|dnaA] to bind cooperatively to DNA [Pubmed|22821970]
Structure
[PDB|2C79] (N-terminal domain)
[AF|P39787]
[wiki|Localization]
Membrane-proximal (Spotty) [Pubmed|16479537]
Expression and Regulation
Operons
genes
[gene|FBA7EAA70F5C9E76463B0C5F85D65D4314FFD40D|asnS]-[gene|C9FEE07601AD28B2651EB881A1D9B34D5082237C|dnaD]-[gene|C352560155F5B2E951B5059794D7B319C1A3AF2C|nth]-[gene|4B2A124B726393544A47791E5A5681F7B766A588|ypoC]
description
[Pubmed|22383849]
Open in new tab

[gene|FBA7EAA70F5C9E76463B0C5F85D65D4314FFD40D|asnS]→[gene|4B2A124B726393544A47791E5A5681F7B766A588|ypoC]

2024-07-16 17:27:37

Jstuelk

99

bddd14432a7dcf7c9a63e653f673da9509b2f9e3

2131D7452E334EEE4F3058582EAA4C1674387033

genes
[gene|C9FEE07601AD28B2651EB881A1D9B34D5082237C|dnaD]-[gene|C352560155F5B2E951B5059794D7B319C1A3AF2C|nth]
description
[Pubmed|21954439]
regulation
constitutively expressed [Pubmed|21954439]
Open in new tab

[gene|C9FEE07601AD28B2651EB881A1D9B34D5082237C|dnaD]→[gene|C352560155F5B2E951B5059794D7B319C1A3AF2C|nth]

2024-07-07 04:03:03

ghost

91

65d592657688b69134681e5f3b8625d248b380d2

2611FA0607D22ABE843DF3A9F08C088FA9A52577

labs
[wiki|Alan Grossman], MIT, Cambridge, MA, USA
References
Reviews
22797751,28075389,36877032
Original Publications
36815589,19707554,15686560,15186423,11585815,20122408,16479537,11222620,19968790,11679082,20587500,21097613,21954439,22821970,30285297,30534966,36416272,37093985

C9FEE07601AD28B2651EB881A1D9B34D5082237C

Page visits: 5445

Time of last update: 2024-07-19 06:29:50

Author of last update: Jstuelk