yqiD
168
geranyltransferase
locus
BSU_24280
Molecular weight
29.59 kDa
pI
5.02
function
biosynthesis of peptidoglycan and teichoic acid
product
geranyltransferase
essential
no
ec
2.5.1.10
synonyms
yqiD, ispA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0142 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,525,789 → 2,526,679
Phenotypes of a mutant
The mutation of ''yqiD'' predisposes cells to grow without a wall [Pubmed|19212404]
The protein
Catalyzed reaction/ biological activity
(2E)-geranyl diphosphate + isopentenyl diphosphate --> (2E,6E)-farnesyl diphosphate + ppi (according to UniProt)
Protein family
FPP/GGPP synthase family (with [protein|3CAEA54E80A0B56EE120B881C8CDBE055AF6BDC1|hepT], according to UniProt)
[wiki|Cofactors]
Magnesium
Structure
[PDB|1RQI]: IspA from ''E. coli''. Co-crystal with substrate isopentyl pyrophosphate and substrate analogue dimethyallyl S-thiolodiphosphate [Pubmed|14672944]
[AF|P54383]
Modification
None
Paralogous protein(s)
[protein|3CAEA54E80A0B56EE120B881C8CDBE055AF6BDC1|hepT]
Biological materials
Mutant
BKE24280 (Δ[gene|C75A4465688BCE9902F9CDC6DE069E36667377E1|yqiD]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE24280 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CCGGTCCGCCAGAAAGCTCG, downstream forward: _UP4_TAAAACGATCCTAATTTGAA
BKK24280 (Δ[gene|C75A4465688BCE9902F9CDC6DE069E36667377E1|yqiD]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK24280 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CCGGTCCGCCAGAAAGCTCG, downstream forward: _UP4_TAAAACGATCCTAATTTGAA
References
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Time of last update: 2024-12-21 18:35:30
Author of last update: Jstuelk