malA
168
6-phospho-alpha-glucosidase
locus
BSU_08180
Molecular weight
50.35 kDa
pI
4.74
function
maltose utilization
product
6-phospho-alpha-glucosidase
essential
no
ec
3.2.1.122
synonyms
malA, glvG, glvA, mdxK
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1486 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
890,022 → 891,371
The protein
Catalyzed reaction/ biological activity
α-maltose 6'-phosphate + H2O --> D-glucose + D-glucose 6-phosphate (according to UniProt)
Protein family
[wiki|Glycosyl hydrolase 4 family] (according to UniProt)
Structure
[PDB|1U8X]
[AF|P54716]
[wiki|Localization]
membrane associated [Pubmed|18763711]
Expression and Regulation
Operons
genes
[gene|C650160C9E5B5F8587CA9E80A57BCCE97D701037|malA]-[gene|AD72489DA260F07B97A213F1F0FBA7CED9471817|glvR]-[gene|E6C7733A12AF9A5322EED444E4A4FF1605A8B20F|malP]
description
[Pubmed|11489864]
regulation
induction by maltose ([protein|search|GlvR]) [Pubmed|11489864]
regulatory mechanism
[protein|AD72489DA260F07B97A213F1F0FBA7CED9471817|glvR]: activation, [Pubmed|11489864], in [regulon|protein:AD72489DA260F07B97A213F1F0FBA7CED9471817|glvR regulon]
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: repression, [Pubmed|11489864], in [regulon|protein:E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|11489864], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Biological materials
Mutant
MGNA-C289 (glvA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2287 NBRP B. subtilis, Japan]
BKE08180 (Δ[gene|C650160C9E5B5F8587CA9E80A57BCCE97D701037|malA]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE08180 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATGACGACCTCCTTGAT, downstream forward: _UP4_TAAATGAAATTCCCCCATTT
BKK08180 (Δ[gene|C650160C9E5B5F8587CA9E80A57BCCE97D701037|malA]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK08180 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATGACGACCTCCTTGAT, downstream forward: _UP4_TAAATGAAATTCCCCCATTT
References
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Time of last update: 2024-12-21 04:08:35
Author of last update: Robert.warneke