reoM
168
effector protein of [protein|DA763F7C2192655C590752C2A285ADF902B11BCA|murAA] degradation by [protein|86A2F2F65290F4471D6FD03B694821C66C180D8A|clpC]-[protein|CB06A70DE7462CEB7AF5D8C28943C878DD56DE1A|clpP]
locus
BSU_27400
Molecular weight
10.10 kDa
pI
4.73
function
control of peptidoglycan biosynthesis
product
regulator of [protein|DA763F7C2192655C590752C2A285ADF902B11BCA|murAA] degradation
essential
no
synonyms
reoM, yrzL
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG4472 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,797,823 → 2,798,089
Phenotypes of a mutant
accumulation of [protein|DA763F7C2192655C590752C2A285ADF902B11BCA|murAA] due to reduced degradation by [protein|86A2F2F65290F4471D6FD03B694821C66C180D8A|clpC]-[protein|CB06A70DE7462CEB7AF5D8C28943C878DD56DE1A|clpP] [pubmed|32469310]
The protein
Protein family
UPF0297 family (single member, according to UniProt)
Structure
[PDB|5US5] (from Enterococcus faecalis, 66% identity) [pubmed|28551334]
[PDB|6TIF] (from Listeria monocytogenes, 68% identity) [pubmed|32469310]
[AF|Q7WY61]
Expression and Regulation
Operons
genes
[gene|C5457FEC46A1AFC6E5B1148B0E5F258B2C3197B2|reoM]-[gene|508FC7117B4CE7AF119B3830AE9DC113CB058039|yrrK]-[gene|A0AA5289F5E92A4B2E18E4F3439F2D412208826E|yrzB]
description
[pubmed|22383849]
genes
[gene|8C5C7F9A585AE89D53EAF1DB3A9AB525B9E30B4A|alaS]-[gene|C5457FEC46A1AFC6E5B1148B0E5F258B2C3197B2|reoM]-[gene|508FC7117B4CE7AF119B3830AE9DC113CB058039|yrrK]-[gene|A0AA5289F5E92A4B2E18E4F3439F2D412208826E|yrzB]
description
[pubmed|22383849]
regulation
induced by alanine limitation ([regulon|T-box|]) [Pubmed|19258532]
regulatory mechanism
T-box: RNA switch, [pubmed|], in [regulon|other_regulator:T-box|T-box]
Biological materials
Mutant
BKE27400 (Δ[gene|C5457FEC46A1AFC6E5B1148B0E5F258B2C3197B2|reoM]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE27400 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACCGTTTTGCACCTCTTTC, downstream forward: _UP4_CAGCATAAAGAGGCGTAAAT
BKK27400 (Δ[gene|C5457FEC46A1AFC6E5B1148B0E5F258B2C3197B2|reoM]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK27400 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACCGTTTTGCACCTCTTTC, downstream forward: _UP4_CAGCATAAAGAGGCGTAAAT
References
Research papers
Page visits: 1966
Time of last update: 2025-01-04 22:06:21
Author of last update: Jstuelk