rnz
168
RNase Z
locus
BSU_23840
Molecular weight
33.87 kDa
pI
5.8
function
processing of CCA-less tRNA precursors
product
endoribonuclease Z
essential
yes
ec
3.1.26.11
synonyms
rnz, yqjK
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1234 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,478,006 → 2,478,929
Phenotypes of a mutant
essential [Pubmed|12682299]
The protein
Catalyzed reaction/ biological activity
Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule (according to UniProt)
3' end maturation of tmRNA [Pubmed|25402410]
Protein family
[wiki|RNase] Z family (single member, according to UniProt)
Structure
[PDB|2FK6] (in complex with tRNA-Thr) [Pubmed|22940585], [PDB|1Y44]
[AF|P54548]
Expression and Regulation
Operons
genes
[gene|C40C5D35ED53D343C8200248FCCB010BAB388054|rnz]-[gene|5189DF2F6144CD2429B5C01B1AD03BAE98307579|rpmGC]
description
[Pubmed|22383849]
labs
[wiki|Ciaran Condon], IBPC, Paris, France [http://www.ibpc.fr/UPR9073/condon/index_en.html Homepage]
References
Reviews
Original Publications
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Time of last update: 2025-01-29 23:47:08
Author of last update: Jstuelk