ywcC
168
transcription repressor ([wiki|TetR family]), controls [gene|C17C296F3EB2E106C380E3B5D784F3FA63F4C9B7|slrA] expression
locus
BSU_38220
Molecular weight
25.96 kDa
pI
8.47
function
control of [gene|C17C296F3EB2E106C380E3B5D784F3FA63F4C9B7|slrA] expression
product
transcription repressor ([wiki|TetR family])
essential
no
synonyms
ywcC, ipa-33d
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1309 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,922,292 → 3,922,963
Phenotypes of a mutant
improved colonization on plant roots (inactivating mutations appear during growth on roots) [pubmed|38206029]
The protein
Protein family
[wiki|TetR family]
[wiki|Domains]
[wiki|HTH tetR-type domain] (aa 11-71) (according to UniProt)
Structure
[AF|P39601]
Expression and Regulation
Operons
genes
[gene|C3D87DAA8DB124D50D2C2B2D424C9608C0DE067F|ywcC]-[gene|FD30C4E458E63E8D6A932B351D4224F1AACD4B1B|gtcA]-[gene|36930CC6FDFCA23D43E264FEA375B78A1434E1BD|galK]-[gene|591428EA1C3D40322BB942429607AF61A90BAF41|galT]
description
[Pubmed|22383849,22893383]
regulation
repressed by glucose ([protein|search|CcpA]) [Pubmed|10666464]
Biological materials
Mutant
MGNA-B230 (ywcC::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1229 NBRP B. subtilis, Japan]
BKE38220 (Δ[gene|C3D87DAA8DB124D50D2C2B2D424C9608C0DE067F|ywcC]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE38220 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATTTTTCTCCTGGCGGT, downstream forward: _UP4_CAGTGAAGTATAGAGAAATA
BKK38220 (Δ[gene|C3D87DAA8DB124D50D2C2B2D424C9608C0DE067F|ywcC]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK38220 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATTTTTCTCCTGGCGGT, downstream forward: _UP4_CAGTGAAGTATAGAGAAATA
References
Reviews
Original Publications
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Time of last update: 2025-01-05 06:02:54
Author of last update: Jstuelk