sipT

sipT
168

signal peptidase I

locus
BSU_14410
Molecular weight
21.71 kDa
pI
9.85
Protein length
Gene length
function
protein secretion
product
signal peptidase I
essential
no
synonyms
sipT

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0681 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,511,308 → 1,511,889
Phenotypes of a mutant
a ''[gene|CDC6971F39F3EEAAE912CB1402EE1BD64D5A12A0|sipS] [gene|C2EAE417DB9250B88BB0E25D4AE760BDE82EFD86|sipT]'' double mutant is not viable [Pubmed|9694797]
The protein
Catalyzed reaction/ biological activity
Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins (according to UniProt)
Protein family
[wiki|peptidase S26 family] (according to UniProt)
Structure
[PDB|4NV4] (from B. anthracis, 44% identity)
[AF|P71013]
Paralogous protein(s)
[protein|CDC6971F39F3EEAAE912CB1402EE1BD64D5A12A0|sipS], [protein|9824F9CF9C2028AF267AC43FE7FD8590E8231AB8|sipU], [protein|ADEEA5E15C100C1DC6E129B9A3E6DECAFCA8C409|sipV]
[wiki|Localization]
cell membrane (according to UniProt)
Expression and Regulation
Operons
genes
[gene|C2EAE417DB9250B88BB0E25D4AE760BDE82EFD86|sipT]
description
[Pubmed|9694797]
regulatory mechanism
[protein|D343D2096664A972026D911E7A17A35C7B1CD1C9|degU]: activation, [Pubmed|9694797], in [regulon|protein:D343D2096664A972026D911E7A17A35C7B1CD1C9|degU regulon]
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[gene|C2EAE417DB9250B88BB0E25D4AE760BDE82EFD86|sipT]

2024-10-01 12:45:56

ghost

72

fdd1722479b998475c28df0a93c3d509c9451403

3FE2EAED18DFE1E303650E41C77DC01651C14532

Biological materials
Mutant
BKE14410 (Δ[gene|C2EAE417DB9250B88BB0E25D4AE760BDE82EFD86|sipT]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE14410 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CAAAGTGTTTCCTCCTAGAC,  downstream forward: _UP4_TAAAAACGCCTTGCTGGCCT
BKK14410 (Δ[gene|C2EAE417DB9250B88BB0E25D4AE760BDE82EFD86|sipT]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK14410 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CAAAGTGTTTCCTCCTAGAC,  downstream forward: _UP4_TAAAAACGCCTTGCTGGCCT
labs
[wiki|Jan Maarten van Dijl], Groningen, Netherlands
References
Reviews
22688815,31286585,34410368
Original Publications
11807061,9325333,9694797,28088521,29358498

C2EAE417DB9250B88BB0E25D4AE760BDE82EFD86

Page visits: 2490

Time of last update: 2024-10-13 21:55:52

Author of last update: Jstuelk