sufU

sufU
168

sulfur shuttle protein, receives sulfur from [protein|88ACE6B79534338F7C72F107B35A0B2384007088|sufS], transfers it to [protein|5991F051C5BAD61A0860BBC64A37DB9D16130998|sufB]

locus
BSU_32680
Molecular weight
16.02 kDa
pI
4.71
Protein length
Gene length
function
transfer of sulfur from [protein|88ACE6B79534338F7C72F107B35A0B2384007088|sufS] to [protein|5991F051C5BAD61A0860BBC64A37DB9D16130998|sufB]
product
sulfur shuttle protein
essential
yes
ec
2.-.-.-
synonyms
sufU, yurV, iscU

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0822 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,357,011 → 3,357,454
Phenotypes of a mutant
essential [Pubmed|12682299]
the mutant is viable and Fe-S clusters are dispensable if [protein|search|IspG ]and [protein|search|IspH ]from the MEP pathway  for  isoprenoid  biosynthesis are bypassed by a heterologous mevalonate pathway which allows B. subtilis to synthesize isopentenyl diphosphate and diphosphomevalonate [pubmed|29292548]
The protein
Catalyzed reaction/ biological activity
transfer of sulfur from [protein|search|SufS ]to [protein|5991F051C5BAD61A0860BBC64A37DB9D16130998|sufB] [pubmed|29292548]
Protein family
NifU family (with [protein|76AA1BFA2810FCC44A340C7BBB1B8540F3D8349F|nfu], according to UniProt)
[wiki|Cofactors]
zinc [Pubmed|24321018]
Structure
[PDB|5XT5] (the [protein|88ACE6B79534338F7C72F107B35A0B2384007088|sufS]2-[protein|C0C30D2A6D3DF7A66063010044D370BD36D27DBF|sufU]2 complex) [pubmed|29235855]
[PDB|2AZH]
[AF|O32163]
Expression and Regulation
Operons
genes
[gene|E966F3808222820C0644DC98F95765B89E6A2551|sufC]-[gene|1A9DA839AB77AF53958CB8426607BEF14F62B85E|sufD]-[gene|88ACE6B79534338F7C72F107B35A0B2384007088|sufS]-[gene|C0C30D2A6D3DF7A66063010044D370BD36D27DBF|sufU]-[gene|5991F051C5BAD61A0860BBC64A37DB9D16130998|sufB]
description
[Pubmed|22383849]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [pubmed|22383849], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
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[gene|E966F3808222820C0644DC98F95765B89E6A2551|sufC]→[gene|5991F051C5BAD61A0860BBC64A37DB9D16130998|sufB]

2024-10-02 03:59:11

Bzhu

112

63d79455b7d41fde1312877ed8143d20d826635d

39B630142CB404BA5FE5465E795D5B1BB8CA4EF6

Biological materials
Mutant
MGNA-B584 (yurV::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1583 NBRP B. subtilis, Japan]
References
Reviews
28882201,34781750,38838856
Original Publications
20087498,20097860,12682299,20233928,20822158,22383849,21236255,24321018,21744456,27382962,29235855,29292548,30855939,36506149

C0C30D2A6D3DF7A66063010044D370BD36D27DBF

Page visits: 3982

Time of last update: 2024-10-03 01:11:33

Author of last update: Jstuelk