sufU
168
sulfur shuttle protein, receives sulfur from [protein|88ACE6B79534338F7C72F107B35A0B2384007088|sufS], transfers it to [protein|5991F051C5BAD61A0860BBC64A37DB9D16130998|sufB]
locus
BSU_32680
Molecular weight
16.02 kDa
pI
4.71
function
transfer of sulfur from [protein|88ACE6B79534338F7C72F107B35A0B2384007088|sufS] to [protein|5991F051C5BAD61A0860BBC64A37DB9D16130998|sufB]
product
sulfur shuttle protein
essential
yes
ec
2.-.-.-
synonyms
sufU, yurV, iscU
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0822 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,357,011 → 3,357,454
Phenotypes of a mutant
essential [Pubmed|12682299]
the mutant is viable and Fe-S clusters are dispensable if [protein|search|IspG ]and [protein|search|IspH ]from the MEP pathway for isoprenoid biosynthesis are bypassed by a heterologous mevalonate pathway which allows B. subtilis to synthesize isopentenyl diphosphate and diphosphomevalonate [pubmed|29292548]
The protein
Catalyzed reaction/ biological activity
transfer of sulfur from [protein|search|SufS ]to [protein|5991F051C5BAD61A0860BBC64A37DB9D16130998|sufB] [pubmed|29292548]
Protein family
NifU family (with [protein|76AA1BFA2810FCC44A340C7BBB1B8540F3D8349F|nfu], according to UniProt)
[wiki|Cofactors]
zinc [Pubmed|24321018]
Structure
[PDB|5XT5] (the [protein|88ACE6B79534338F7C72F107B35A0B2384007088|sufS]2-[protein|C0C30D2A6D3DF7A66063010044D370BD36D27DBF|sufU]2 complex) [pubmed|29235855]
[PDB|2AZH]
[AF|O32163]
Expression and Regulation
Operons
genes
[gene|E966F3808222820C0644DC98F95765B89E6A2551|sufC]-[gene|1A9DA839AB77AF53958CB8426607BEF14F62B85E|sufD]-[gene|88ACE6B79534338F7C72F107B35A0B2384007088|sufS]-[gene|C0C30D2A6D3DF7A66063010044D370BD36D27DBF|sufU]-[gene|5991F051C5BAD61A0860BBC64A37DB9D16130998|sufB]
description
[Pubmed|22383849]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [pubmed|22383849], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Biological materials
Mutant
MGNA-B584 (yurV::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1583 NBRP B. subtilis, Japan]
References
Reviews
Original Publications
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Time of last update: 2024-12-30 21:21:05
Author of last update: Jstuelk