hxlA
168
3-hexulose-6-phosphate synthase
locus
BSU_03460
Molecular weight
22.43 kDa
pI
4.56
function
ribulose monophosphate pathway for formaldehyde fixation
product
3-hexulose-6-phosphate synthase
essential
no
ec
4.1.2.43
synonyms
hxlA, yckG
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0269 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
375,166 → 375,798
The protein
Catalyzed reaction/ biological activity
D-ribulose 5-phosphate + formaldehyde --> D-arabino-hex-3-ulose 6-phosphate (according to UniProt)
Protein family
HPS/KGPDC family (single member, according to UniProt)
Structure
[PDB|3F4W] (from Salmonella typhimurium, 44% identity)
[AF|P42405]
Expression and Regulation
Operons
genes
[gene|BF480721B89661BFFE6632BB10C5F4DC29951784|hxlA]-[gene|FB0CEA291CA4EC5FB8410050E61B89EDBA1771F9|hxlB]
description
[Pubmed|10572115]
regulation
induction by formaldehyde ([protein|search|HxlR]) [Pubmed|10572115]
regulatory mechanism
[protein|D9A187961CFB9496A6712E9E48AAD384357A3E1C|hxlR]: activation, [Pubmed|10572115], in [regulon|protein:D9A187961CFB9496A6712E9E48AAD384357A3E1C|hxlR regulon]
Biological materials
Mutant
MGNA-C057 (yckG::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2055 NBRP B. subtilis, Japan]
BKE03460 (Δ[gene|BF480721B89661BFFE6632BB10C5F4DC29951784|hxlA]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE03460 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTGTTGATCCACTCCCTT, downstream forward: _UP4_CTGATTGTCCAAGGATAACT
BKK03460 (Δ[gene|BF480721B89661BFFE6632BB10C5F4DC29951784|hxlA]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK03460 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTGTTGATCCACTCCCTT, downstream forward: _UP4_CTGATTGTCCAAGGATAACT
References
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Time of last update: 2025-04-07 07:12:14
Author of last update: Melvin.boenninger