uvrX
168
UV-damage repair protein
locus
BSU_21500
Molecular weight
46.57 kDa
pI
9.63
function
DNA repair after UV damage
product
UV-damage repair protein
essential
no
synonyms
uvrX, yolE
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0389 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,270,407 → 2,271,657
Phenotypes of a mutant
reduced formation of [gene|F1969E4C7BAAF70BCBE570F58350C12A3E417539|rpsB] or [gene|144D952B05EBBFF41EC92DF906543EA00475FE69|rpsE] suppressor mutants after mitomycin treatment [pubmed|34339280]
The protein
Protein family
[wiki|DNA polymerase type-Y family] (according to UniProt)
[wiki|Domains]
[wiki|UmuC domain] (aa 12-196) (according to UniProt)
Structure
[AF|O31990]
Paralogous protein(s)
[protein|C87D33852F263A553CA747608E6200E4AD8344B5|polY1], [protein|F0BC150F59730E64BA9AB3F979544EF6B5CC4E9E|polY2]
Expression and Regulation
Operons
genes
[gene|A9D5625FF5F1A3845FF6F8A290F647CCA73D39EF|yolD]-[gene|BE8D5E038C0FD748C0F9C3F18DCA601BFFE8EA52|uvrX]
description
[Pubmed|16267290]
regulation
induced by DNA damage ([protein|search|LexA]) [Pubmed|16267290]
regulatory mechanism
[protein|D267AF38B0CF107042326E9B8F3DD3C9C85840E4|lexA]: repression, [Pubmed|16267290], in [regulon|protein:D267AF38B0CF107042326E9B8F3DD3C9C85840E4|lexA regulon]
Biological materials
Mutant
BKE21500 (Δ[gene|BE8D5E038C0FD748C0F9C3F18DCA601BFFE8EA52|uvrX]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE21500 BGSC], [Pubmed|28189581], upstream reverse: _UP1_AATCAATCATTGTATGTAAC, downstream forward: _UP4_TAAGATAAATTTAAACTTAT
BKK21500 (Δ[gene|BE8D5E038C0FD748C0F9C3F18DCA601BFFE8EA52|uvrX]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK21500 BGSC], [Pubmed|28189581], upstream reverse: _UP1_AATCAATCATTGTATGTAAC, downstream forward: _UP4_TAAGATAAATTTAAACTTAT
References
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Time of last update: 2024-12-21 03:39:51
Author of last update: Jstuelk