uvrX

uvrX
168

UV-damage repair protein

locus
BSU_21500
Molecular weight
46.57 kDa
pI
9.63
Protein length
Gene length
function
DNA repair after UV damage
product
UV-damage repair protein
essential
no
synonyms
uvrX, yolE

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0389 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,270,407 → 2,271,657
Phenotypes of a mutant
reduced formation of [gene|F1969E4C7BAAF70BCBE570F58350C12A3E417539|rpsB] or [gene|144D952B05EBBFF41EC92DF906543EA00475FE69|rpsE] suppressor mutants after mitomycin treatment [pubmed|34339280]
The protein
Protein family
[wiki|DNA polymerase type-Y family] (according to UniProt)
[wiki|Domains]
[wiki|UmuC domain] (aa 12-196) (according to UniProt)
Structure
[AF|O31990]
Paralogous protein(s)
[protein|C87D33852F263A553CA747608E6200E4AD8344B5|polY1], [protein|F0BC150F59730E64BA9AB3F979544EF6B5CC4E9E|polY2]
Expression and Regulation
Operons
genes
[gene|A9D5625FF5F1A3845FF6F8A290F647CCA73D39EF|yolD]-[gene|BE8D5E038C0FD748C0F9C3F18DCA601BFFE8EA52|uvrX]
description
[Pubmed|16267290]
regulation
induced by DNA damage ([protein|search|LexA]) [Pubmed|16267290]
regulatory mechanism
[protein|D267AF38B0CF107042326E9B8F3DD3C9C85840E4|lexA]: repression, [Pubmed|16267290], in [regulon|protein:D267AF38B0CF107042326E9B8F3DD3C9C85840E4|lexA regulon]
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[gene|A9D5625FF5F1A3845FF6F8A290F647CCA73D39EF|yolD]→[gene|BE8D5E038C0FD748C0F9C3F18DCA601BFFE8EA52|uvrX]

2024-10-14 08:18:57

ghost

69

75abea45b56916be6c2da15dea6c26c9903e3f54

4B3A377D69E222FC756C7EB6DE6DAB9836226A58

Biological materials
Mutant
BKE21500 (Δ[gene|BE8D5E038C0FD748C0F9C3F18DCA601BFFE8EA52|uvrX]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE21500 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_AATCAATCATTGTATGTAAC,  downstream forward: _UP4_TAAGATAAATTTAAACTTAT
BKK21500 (Δ[gene|BE8D5E038C0FD748C0F9C3F18DCA601BFFE8EA52|uvrX]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK21500 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_AATCAATCATTGTATGTAAC,  downstream forward: _UP4_TAAGATAAATTTAAACTTAT
References
16267290,30916324,34339280

BE8D5E038C0FD748C0F9C3F18DCA601BFFE8EA52

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Time of last update: 2024-10-15 20:44:17

Author of last update: Jstuelk