fecD
168
iron/citrate [wiki|ABC transporter] (permease)
locus
BSU_07510
Molecular weight
34.94 kDa
pI
9.7
function
[wiki|acquisition of iron]
product
iron/citrate [wiki|ABC transporter] (permease)
essential
no
synonyms
fecD, yfmD
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0609 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
824,714 → 825,715
The protein
Protein family
[wiki|Binding-protein-dependent transport system permease family] (according to UniProt)
[wiki|FecCD subfamily] (according to UniProt)
Structure
[PDB|4G1U] (from ''Yersinia pestis'', the [protein|BDAA56484E05DA3C1CB0CA09873A365657999679|fecD]-[protein|800EAB1D8617589CCAC68FB874EFCDE4C77962E1|fecE]-[protein|E76640F895261DA34AD2342B54B43D11857AEA9A|fecF] complex, 34% identity) [Pubmed|23142986]
[AF|O34933]
Paralogous protein(s)
[protein|3E1C925C31C00803982C8EB1C6B025C22DB4A828|fhuB], [protein|81494D4E7E52531802C3C0D0073739DA9375F5DF|yfiZ], [protein|57402D137E3D3791CAF0696421224F4E1DC1BA48|feuB], [protein|800EAB1D8617589CCAC68FB874EFCDE4C77962E1|fecE]
[wiki|Localization]
cell membrane [Pubmed|10092453]
Expression and Regulation
Operons
genes
[gene|569510093E5B69A0368205920A21A81CADF030E9|fecC]-[gene|BDAA56484E05DA3C1CB0CA09873A365657999679|fecD]-[gene|800EAB1D8617589CCAC68FB874EFCDE4C77962E1|fecE]-[gene|E76640F895261DA34AD2342B54B43D11857AEA9A|fecF]
description
[Pubmed|16672620]
regulation
immediately induced upon iron starvation (first wave to allow iron uptake) ([protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|fur]) [Pubmed|29133393,16672620,12354229]
regulatory mechanism
[protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|fur]: repression, [Pubmed|16672620,12354229], in [regulon|protein:F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|fur regulon]
Biological materials
Mutant
MGNA-C330 (yfmD::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2328 NBRP B. subtilis, Japan]
BKE07510 (Δ[gene|BDAA56484E05DA3C1CB0CA09873A365657999679|fecD]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE07510 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAACAGTCTCACTTCCTTAC, downstream forward: _UP4_GCAAGGAAAGGGCGAAACCT
BKK07510 (Δ[gene|BDAA56484E05DA3C1CB0CA09873A365657999679|fecD]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK07510 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAACAGTCTCACTTCCTTAC, downstream forward: _UP4_GCAAGGAAAGGGCGAAACCT
References
Page visits: 4472
Time of last update: 2024-12-21 04:53:44
Author of last update: Jstuelk