ywpB
168
ß-hydroxyacyl-(acyl carrier protein) dehydratase
locus
BSU_36370
Molecular weight
14.63 kDa
pI
9.36
function
fatty acid biosynthesis
product
β-hydroxyacyl-ACP dehydratase
essential
yes
ec
4.2.1.59
synonyms
ywpB, fabZ
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0764 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,743,732 → 3,744,157
Phenotypes of a mutant
essential [Pubmed|23109554]
The protein
Catalyzed reaction/ biological activity
(3R)-hydroxyacyl-[ACP] --> (2E)-enoyl-[ACP] + H2O (according to UniProt)
Protein family
thioester dehydratase family (with [protein|65506215AE58BF53C57599E566E4F78514DB45AA|ycsD], according to UniProt)
Structure
[PDB|3D6X] (from ''Campylobacter jejuni'', 45% identity, 67% similarity) [Pubmed|19280690]
[AF|P94584]
Paralogous protein(s)
[protein|65506215AE58BF53C57599E566E4F78514DB45AA|ycsD]
Expression and Regulation
Operons
genes
[gene|BDA23FA513C240B07DC109BB62A7A5EB96B20965|ywpB]-[gene|7F7BC285A1D02B031575BA7E980293CD2962C84A|mscL]
description
[Pubmed|22383849]
regulation
expressed in logarithmic phase [Pubmed|19252899]
Biological materials
Mutant
MGNA-B265 (ywpB::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1264 NBRP B. subtilis, Japan]
References
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Time of last update: 2024-12-05 16:40:03
Author of last update: Jstuelk