yvmC
168
cyclodipeptide synthase
locus
BSU_35070
Molecular weight
28.36 kDa
pI
6.61
function
biosynthesis of the extracellular iron chelator pulcherrimin
product
cyclodipeptide synthase
essential
no
synonyms
yvmC
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms
This gene is a member of the following regulons
Gene
Coordinates
3,603,821 → 3,604,567
The protein
Catalyzed reaction/ biological activity
synthesis of the cyclic dipeptide cyclo-L-leucyl-L-leucyl with the corresponding charged tRNAs as substrates in an [metabolite|ATP]-dependent manner [Pubmed|19430487]
2 L-leucyl-tRNALeu --> cyclo(L-leucyl-L-leucyl) + 2 H+ + 2 tRNALeu (according to UniProt)
Protein family
CDPS family (single member, according to UniProt)
Structure
[PDB|3S7T] (from ''B. licheniformis'', 70% identity, 86% similarity) [Pubmed|21325056]
[AF|O34351]
Expression and Regulation
Operons
genes
[gene|BCE1D8CDDF07396583FF50C4C192785545244BE2|yvmC]-[gene|D63EDBB6AA33708E8352F6208A9BA18CAEE0DC53|cypX]
description
[http://www.liebertonline.com/doi/pdf/10.1089/ind.2006.2.66 Reference]
expression
expression is heterogeneous [pubmed|35171018]
regulatory mechanism
[protein|E5110D9C36E8C55AFD1419987B14A53232165F20|abrB]: repression, [Pubmed|38753885,20817675], in [regulon|protein:E5110D9C36E8C55AFD1419987B14A53232165F20|abrB regulon]
[protein|0D555F2AB7DC863E6FF388888308E980514DB719|pchR]: repression, [pubmed|38753885], in [regulon|protein:0D555F2AB7DC863E6FF388888308E980514DB719|pchR regulon]
[protein|F7FD94CE7AB290FBFD3A9B88F204961668F9B42C|scoC]: repression, [pubmed|38753885], in [regulon|protein:F7FD94CE7AB290FBFD3A9B88F204961668F9B42C|scoC regulon]
Biological materials
Mutant
BKE35070 (Δ[gene|BCE1D8CDDF07396583FF50C4C192785545244BE2|yvmC]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE35070 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTCATTCACCCCTAAAA, downstream forward: _UP4_TGATAGGGGGAGTAAAACAT
BKK35070 (Δ[gene|BCE1D8CDDF07396583FF50C4C192785545244BE2|yvmC]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK35070 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTCATTCACCCCTAAAA, downstream forward: _UP4_TGATAGGGGGAGTAAAACAT
References
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Time of last update: 2024-12-25 10:25:46
Author of last update: Jstuelk