dfrA
168
dihydrofolate reductase
locus
BSU_21810
Molecular weight
19.03 kDa
pI
5.22
function
biosynthesis of folate
product
dihydrofolate reductase
essential
yes
ec
1.5.1.3
synonyms
dfrA, tmp
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0262 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,296,603 → 2,297,109
Phenotypes of a mutant
essential [Pubmed|12682299]
The protein
Catalyzed reaction/ biological activity
(6S)-5,6,7,8-tetrahydrofolate + NADP+ --> 7,8-dihydrofolate + H+ + NADPH (according to UniProt)
Protein family
dihydrofolate reductase family (single member, according to UniProt)
[wiki|Domains]
DHFR domain (aa 1-159) (according to UniProt)
Structure
[PDB|8UVZ] (complex with NADP+ and folate) [pubmed|37986818]
[PDB|1ZDR] (Geobacillus stearothermophilus)
[AF|P11045]
Expression and Regulation
Operons
genes
[gene|8B515C789439354F870023E69077D2C1D709E046|ypjP]-[gene|2CB3BAF17F59A858D249619A436EF660CAA58DD5|ypjQ]-[gene|9F9643D51E9ABA537892B19312491697CECDDCCF|thyB]-[gene|B740E971204AC14BA456B8C93A86D4BDC29524FF|dfrA]-[gene|9D1DAA5E69DD12FDE0FB33EA0863E0CB214120EC|ypkP]
description
[Pubmed|22383849]
genes
[gene|9F9643D51E9ABA537892B19312491697CECDDCCF|thyB]-[gene|B740E971204AC14BA456B8C93A86D4BDC29524FF|dfrA]
description
[Pubmed|2840350]
regulation
weak induction in the presence of glucose ([protein|search|CcpN]) [Pubmed|19732150]
regulatory mechanism
[protein|2234D81F8F9B92EAF1CF6F73BEC92D4DE54E2636|ccpN]: activation, weak, in [regulon|protein:2234D81F8F9B92EAF1CF6F73BEC92D4DE54E2636|ccpN regulon]
References
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Time of last update: 2025-03-30 20:40:04
Author of last update: Jstuelk