hisJ
168
histidinol phosphate phosphatase
locus
BSU_29620
Molecular weight
30.33 kDa
pI
5.06
function
biosynthesis of histidine
product
histidinol phosphate phosphatase
essential
no
ec
3.1.3.15
synonyms
hisJ, ytvP
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1387 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,031,614 → 3,032,420
Phenotypes of a mutant
auxotroph for histidine
The protein
Catalyzed reaction/ biological activity
H2O + L-histidinol phosphate --> L-histidinol + phosphate (according to UniProt)
Protein family
PHP hydrolase family (single member, according to UniProt)
Structure
[PDB|3DCP] (from Listeria monocytogenes, 35% identity)
[AF|O34411]
Expression and Regulation
Operons
genes
[gene|B6C931049CF7353042EB3714976735189ADAF0FD|hisJ]-[gene|B940BDAFDAFF086F503613B90526230A7D383B3D|S1129]-[gene|02AB87E514281E00FA23284BE1B92925A6CFD71E|S1130]-[gene|2BE3320FA86A7DF58A9FFF4403A4A874859DBBB7|S1131]-[gene|6EE8DFD3C5EB5A6DBE13685F335776C266488FF8|S1132]-[gene|65F36DED62B1640FBE59ACBBBCC8B469F57B14AC|ytsP]
description
[Pubmed|22383849]
Biological materials
Mutant
MGNA-A427 (ytvP::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/427 NBRP B. subtilis, Japan]
BKE29620 (Δ[gene|B6C931049CF7353042EB3714976735189ADAF0FD|hisJ]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE29620 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTGATGTCACCCCATGAA, downstream forward: _UP4_TATGAGGCGTTTTTGGAACG
BKK29620 (Δ[gene|B6C931049CF7353042EB3714976735189ADAF0FD|hisJ]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK29620 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTGATGTCACCCCATGAA, downstream forward: _UP4_TATGAGGCGTTTTTGGAACG
labs
[wiki|Stephane Aymerich], Microbiology and Molecular Genetics, INRA Paris-Grignon, France
References
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Time of last update: 2025-04-16 18:12:27
Author of last update: Melvin.boenninger