tcyC
168
cystine and diaminopimelate [wiki|ABC transporter], ATP-binding protein
locus
BSU_03590
Molecular weight
27.64 kDa
pI
7.19
function
cystine and diaminopimelate uptake
product
cystine and diaminopimelate [wiki|ABC transporter], ATP-binding protein
essential
no
synonyms
tcyC, yckI
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1126 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
409,208 → 409,951
The protein
Catalyzed reaction/ biological activity
uptake of cystine and diaminopimelate [pubmed|29995990]
Protein family
[wiki|ABC transporter superfamily] (according to UniProt)
L-cystine importer (TC 3.A.1.3.14) family (single member, according to UniProt)
[wiki|Domains]
[wiki|ABC transporter domain] (aa 2-240) (according to UniProt)
Structure
[PDB|2Q0H] (in complex with ADP-Mg2+, Geobacillus stearothermophilus, 55% identity)
[AF|P39456]
Paralogous protein(s)
[protein|F8C800CF71D21A1F3265977C4F0EE191D0FFE36A|yxeO], [protein|0D5BC94E21D51373A50D61CE3D0895B3DB28F6B3|pstBB], [protein|0F8048267EC038D8CF673317D969BA27735473A7|yvrO], [protein|468BEA9EAEA589D683DB79B2C689A5C6A22AB67F|glnQ], [protein|6882EF93EC82872B25C88104F62D6603D2514890|artR], [protein|B24763A732111026D21C828FF9BE73FB22A123CF|tcyN], [protein|434BCED6953BE07D592AC229264C5AD0D04CBAF6|pstBA]
[wiki|Localization]
attached to the membrane via [protein|9400DF25487461E3738DDDC72BDDB1589281409D|tcyB] [Pubmed|10092453]
Expression and Regulation
Operons
genes
[gene|2056F8EEDF9D3027CFD808E8D0C5DF544DBDD3F3|tcyA]-[gene|9400DF25487461E3738DDDC72BDDB1589281409D|tcyB]-[gene|B453986691E1231A1C565D469A2A60EBFF2F6BD3|tcyC]
description
[Pubmed|22383849,15262924]
regulation
strongly repressed in response to glucose starvation in M9 medium [Pubmed|23033921]
Biological materials
Mutant
MGNA-C004 (yckI::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2002 NBRP B. subtilis, Japan]
BKE03590 (Δ[gene|B453986691E1231A1C565D469A2A60EBFF2F6BD3|tcyC]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE03590 BGSC], [Pubmed|28189581], upstream reverse: _UP1_AACGGTAAGCATACTCGGAA, downstream forward: _UP4_TAATAAGAAAAACAGAGCGT
BKK03590 (Δ[gene|B453986691E1231A1C565D469A2A60EBFF2F6BD3|tcyC]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK03590 BGSC], [Pubmed|28189581], upstream reverse: _UP1_AACGGTAAGCATACTCGGAA, downstream forward: _UP4_TAATAAGAAAAACAGAGCGT
References
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Time of last update: 2024-10-10 17:10:25
Author of last update: Melvin.boenninger