cccA
168
cytochrome c550
locus
BSU_25190
Molecular weight
12.63 kDa
pI
5.28
function
respiration
product
cytochrome c550
essential
no
synonyms
cccA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG2010 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,599,523 → 2,599,885
The protein
[wiki|Domains]
transmembrane domain at the N-terminus (aa 5 -25) [Pubmed|2166045]
[wiki|Cofactors]
heme c [Pubmed|2166045]
Structure
[AF|P24469]
[wiki|Localization]
cell membrane (outer side) [Pubmed|2166045]
Expression and Regulation
Operons
genes
[gene|B3EBB417FB2DE3CE6BAFB910E1913785C162EABF|cccA]
description
[Pubmed|22383849]
regulation
carbon catabolite repression ([protein|search|CcpA]) [Pubmed|22900538,11361075,12850135]
regulatory mechanism
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: repression, cre site overlaps -35 region of the promoter [Pubmed|11361075], in [regulon|protein:E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA regulon]
[protein|E5110D9C36E8C55AFD1419987B14A53232165F20|abrB]: repression, [Pubmed|20817675], in [regulon|protein:E5110D9C36E8C55AFD1419987B14A53232165F20|abrB regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|11361075], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
additional information
the mRNA is very stable (half-life > 15 min) [http://www.ncbi.nlm.nih.gov/sites/entrez/12884008 PubMed]
Biological materials
Mutant
BKE25190 (Δ[gene|B3EBB417FB2DE3CE6BAFB910E1913785C162EABF|cccA]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE25190 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTCCCTTCCCCCTTTTT, downstream forward: _UP4_TAAAAGAACTATTTTTCTCT
BKK25190 (Δ[gene|B3EBB417FB2DE3CE6BAFB910E1913785C162EABF|cccA]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK25190 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTCCCTTCCCCCTTTTT, downstream forward: _UP4_TAAAAGAACTATTTTTCTCT
References
Reviews
Original Publications
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Time of last update: 2024-11-10 21:35:09
Author of last update: Jstuelk