arsR
168
transcriptional regulator of the [wiki|ArsR family], arsenic resistance operon repressor
locus
BSU_25810
Molecular weight
12.15 kDa
pI
4.88
function
regulation of As (III) efflux
product
transcription repressor ([wiki|ArsR family])
essential
no
synonyms
arsR, yqcJ
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0640 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,657,317 → 2,657,634
The protein
Protein family
[wiki|ArsR family]
[wiki|Domains]
[wiki|HTH arsR-type domain] (aa 4-99) (according to UniProt)
Structure
[PDB|1U2W] (CadC from Staphylococcus aureus, 36% identity) [pubmed|15937183]
[AF|P45949]
Expression and Regulation
Operons
genes
[gene|B3D88B9C89154B77D77FB833CA16FD4F4E29FE96|arsR]-[gene|74B1AF103E6B236609CD184A1A409A9A04857181|yqcK]-[gene|B749D54249A28A471EF796903A34622A16D5B0BB|arsB]-[gene|DB3527FB78D0B7C144D1699D665788184F19AFE0|arsC]
description
[Pubmed|9537360]
regulation
expressed early during sporulation in the forespore ([protein|search|SigF]) [Pubmed|16497325]
regulatory mechanism
[protein|B3D88B9C89154B77D77FB833CA16FD4F4E29FE96|arsR]: repression, [Pubmed|9537360], in [regulon|protein:B3D88B9C89154B77D77FB833CA16FD4F4E29FE96|arsR regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|9537360], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
[protein|CFF318EE6CACDEE763FBF96A2ABB46E944679AAA|sigF]: sigma factor, [Pubmed|16497325], in [regulon|protein:CFF318EE6CACDEE763FBF96A2ABB46E944679AAA|sigF regulon]
Biological materials
Mutant
BKE25810 (Δ[gene|B3D88B9C89154B77D77FB833CA16FD4F4E29FE96|arsR]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE25810 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTCATATCGCCTTCTTTA, downstream forward: _UP4_TAAAAAAATTTTTTAGGTAT
BKK25810 (Δ[gene|B3D88B9C89154B77D77FB833CA16FD4F4E29FE96|arsR]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK25810 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTCATATCGCCTTCTTTA, downstream forward: _UP4_TAAAAAAATTTTTTAGGTAT
References
Reviews
Original Publications
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Time of last update: 2024-12-30 11:15:13
Author of last update: Jstuelk