oppB
168
oligopeptide [wiki|ABC transporter] (permease)
locus
BSU_11440
Molecular weight
33.92 kDa
pI
9.86
function
initiation of [wiki|sporulation], competence development
product
oligopeptide [wiki|ABC transporter] (permease)
essential
no
synonyms
oppB, spo0KB
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0601 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,221,594 → 1,222,529
Phenotypes of a mutant
reduced survival after [category|SW.3.1.1|DNA replication] arrest imposed by inhibition of [protein|FB97DF0C147FB29944F60214CB9BC1803861DAA0|polC] activity [pubmed|36574412]
The protein
Catalyzed reaction/ biological activity
required for the uptake of quorum sensing peptides such as [protein|4FA7D6E6316A6FC71C10C692D125833263894020|phrH] [Pubmed|21908671]
Protein family
[wiki|Binding-protein-dependent transport system permease family] (according to UniProt)
[wiki|OppBC subfamily] (according to UniProt)
[wiki|Domains]
[wiki|ABC transmembrane type-1 domain] (aa 94-295) (according to UniProt)
Structure
[AF|P24138]
Paralogous protein(s)
[protein|C6EB94EACDA544700A468545BD1FDA91C5FD82FB|appB], [protein|062AE5FB4C778178A7F6833CB8BD9D631E461E89|dppB]
[wiki|Localization]
cell membrane [Pubmed|10092453,18763711]
Expression and Regulation
Operons
genes
[gene|302DFA46D73E18C4663468ED6033C55056744475|oppA]-[gene|B0A3C7B253FB1DA1D4BC9D1D564905ECE8A65BC1|oppB]-[gene|DDBCE73B6AF39E5D669475479186C93F287DA9FC|oppC]-[gene|05752B9C4EA7ACD579D65D028B7DF1861F3840CB|oppD]-[gene|38AD697B6C9967B8BD7496E31264A21F6D0A9DEE|oppF]
description
[Pubmed|1901616]
regulation
expressed in the absence of good nitrogen sources (glutamine or ammonium) ([protein|search|TnrA]) [Pubmed|12823818]
regulatory mechanism
[protein|857EF1AC54DEA0690C01B7F8CEFFD16312C58F20|tnrA]: activation, [Pubmed|12823818], in [regulon|protein:857EF1AC54DEA0690C01B7F8CEFFD16312C58F20|tnrA regulon]
[protein|90ACE0DECA58D3C1A55E135120F7A0C1C920571C|codY]: repression, no derepression occurs, however, in a [protein|90ACE0DECA58D3C1A55E135120F7A0C1C920571C|codY] mutant, due to increased repression by [protein|F7FD94CE7AB290FBFD3A9B88F204961668F9B42C|scoC] [Pubmed|25966844], in [regulon|protein:90ACE0DECA58D3C1A55E135120F7A0C1C920571C|codY regulon]
[protein|F7FD94CE7AB290FBFD3A9B88F204961668F9B42C|scoC]: repression, [Pubmed|10383984], in [regulon|protein:F7FD94CE7AB290FBFD3A9B88F204961668F9B42C|scoC regulon]
additional information
A [protein|search|ncRNA] is predicted between '[protein|search|trpS]' and '[protein|search|oppA]' [PubMed|20525796]
Biological materials
Mutant
GP2063 (''[gene|B0A3C7B253FB1DA1D4BC9D1D564905ECE8A65BC1|oppB]''::''spc''), available in [wiki|Jörg Stülke]'s lab
GP2097 (D(''[gene|302DFA46D73E18C4663468ED6033C55056744475|oppA]-[gene|B0A3C7B253FB1DA1D4BC9D1D564905ECE8A65BC1|oppB]-[gene|DDBCE73B6AF39E5D669475479186C93F287DA9FC|oppC]-[gene|05752B9C4EA7ACD579D65D028B7DF1861F3840CB|oppD]-[gene|38AD697B6C9967B8BD7496E31264A21F6D0A9DEE|oppF]'')::''aphA3''), available in [wiki|Jörg Stülke]'s lab
BKE11440 (Δ[gene|B0A3C7B253FB1DA1D4BC9D1D564905ECE8A65BC1|oppB]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE11440 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAGGGGGAACACCTCCATG, downstream forward: _UP4_AAAGCAAAGAAAGGAGCCTA
BKK11440 (Δ[gene|B0A3C7B253FB1DA1D4BC9D1D564905ECE8A65BC1|oppB]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK11440 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAGGGGGAACACCTCCATG, downstream forward: _UP4_AAAGCAAAGAAAGGAGCCTA
References
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Time of last update: 2024-12-21 20:29:20
Author of last update: Jstuelk