priA
168
primosomal replication factor Y, part of the [wiki|replisome], required for survival of DNA damage
locus
BSU_15710
Molecular weight
91.16 kDa
pI
8.28
function
[category|SW.3.1.1|DNA replication] initiation
product
primosomal replication factor Y
essential
yes
ec
3.6.4.-
synonyms
priA, yloJ
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1198 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,644,068 → 1,646,485
Phenotypes of a mutant
essential [Pubmed|12682299]
The protein
Catalyzed reaction/ biological activity
binds stalled replication forks and initiates fork restart allowing for chromosomes to be fully duplicated under stressful conditions [pubmed|35007156]
binds to abasic DNA lesions [pubmed|37250769]
Protein family
[wiki|helicase family] (according to UniProt)
[wiki|Domains]
[wiki|Helicase ATP-binding domain] (aa 282-448) (according to UniProt)
[wiki|Helicase C-terminal domain] (aa 545-699) (according to UniProt)
Structure
[PDB|4NL4] (from ''Klebsiella pneumoniae'', 38% identity) [Pubmed|24379377]
[AF|P94461]
Expression and Regulation
Operons
genes
[gene|A57D2C1536F3E93CD687C28C59FF297355CAB303|yloC]-[gene|6AF1CB8998BE9C71DF4F1201A7F74FF7E75CB799|remA]-[gene|1BC994DE60A7BB35DEDD7154581A396D29AA94A7|gmk]-[gene|921933B6B893083F151AABDEDCBC65F2E55677BE|yloH]-[gene|2B67C63442F28F6BCBA3BA6DE4B563C73E8DF16C|coaBC]-[gene|AF5ADDA2A98EC18BB72A81AA0336E639C0D1F430|priA]-[gene|3D41FB608DB70B9482312A1BBCCDBDA7FB713AFA|defA]-[gene|06971E9AAB033E2878914A76645F99E97CE8A90A|fmt]-[gene|1370D8783450D538C71E3DE8EA5B37DFEE073FF0|yloM]-[gene|5DEBD84E5937DB8B7F29C729FAA0076DF86A5451|yloN]
description
[pubmed|22383849]
additional information
the mRNA is cleaved by [protein|BAB297D18F94FFA67B8D12A684AB4D1BCDFB4981|RNase III] [PubMed|26883633]
References
Reviews
Original Publications
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Time of last update: 2024-10-12 16:59:52
Author of last update: Jstuelk