phrF
168
response regulator aspartate phosphatase (RapF) regulator, antagonizes the RapF-ComA interaction
locus
BSU_37470
Molecular weight
4.07 kDa
pI
10.24
function
control of ComA activity
product
phosphatase (RapF) regulator
essential
no
ec
null
synonyms
phrF, ywhI
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms
This gene is a member of the following regulons
Gene
Coordinates
3,847,130 → 3,847,249
The protein
Catalyzed reaction/ biological activity
binds to [protein|1F860F4E66A3D503D5A97F17D4AB0504BEFE7F9D|rapF], this results in the inability of [protein|1F860F4E66A3D503D5A97F17D4AB0504BEFE7F9D|rapF] to interact with [protein|7832489F11F606BCF637EC23BAAB41AD10237EBB|comA] [Pubmed|15968044]
Protein family
[wiki|phr family] (according to UniProt)
Structure
[AF|P71001]
Expression and Regulation
Operons
genes
[gene|1F860F4E66A3D503D5A97F17D4AB0504BEFE7F9D|rapF]-[gene|AEBEDF43C56A9A54716D781D062067B69818FAF4|phrF]
description
[Pubmed|11466295]
regulation
PhrF accumulates at high cell density
regulatory mechanism
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: repression, [Pubmed|12850135], in [regulon|protein:E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA regulon]
[protein|7832489F11F606BCF637EC23BAAB41AD10237EBB|comA]: activation, [Pubmed|15968044], in [regulon|protein:7832489F11F606BCF637EC23BAAB41AD10237EBB|comA regulon]
sigma factors
[protein|DC3449D5F195E5C2E9E14FEC95396C8F1FDF73B4|sigH]: sigma factor, [Pubmed|11466295], in [regulon|protein:DC3449D5F195E5C2E9E14FEC95396C8F1FDF73B4|sigH regulon]
genes
[gene|AEBEDF43C56A9A54716D781D062067B69818FAF4|phrF]
description
[Pubmed|11466295]
regulation
PhrF accumulates at high cell density
Biological materials
Mutant
BKE37470 (Δ[gene|AEBEDF43C56A9A54716D781D062067B69818FAF4|phrF]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE37470 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TAGAGCCAGACAAGAGAGTA, downstream forward: _UP4_TAACCGCCGTCCATCGGCGG
BKK37470 (Δ[gene|AEBEDF43C56A9A54716D781D062067B69818FAF4|phrF]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK37470 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TAGAGCCAGACAAGAGAGTA, downstream forward: _UP4_TAACCGCCGTCCATCGGCGG
References
Reviews
Original Publications
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Time of last update: 2024-12-20 12:53:29
Author of last update: Jstuelk