ppaC
168
inorganic pyrophosphatase
locus
BSU_40550
Molecular weight
33.83 kDa
pI
4.51
function
recovery of phosphate ions from pyrophosphate
product
inorganic pyrophosphatase
essential
yes
ec
3.6.1.1
synonyms
ppaC, yybQ
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1227 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
4,168,204 4,169,133
Phenotypes of a mutant
essential [Pubmed|12682299]
The protein
Catalyzed reaction/ biological activity
diphosphate + H2O --> H+ + 2 phosphate (according to UniProt)
Protein family
PPase class C family (single member, according to UniProt)
[wiki|Domains]
[wiki|DHH-DHHA1 domain]
[wiki|Cofactors]
Mn2+ [pubmed|17095506]
Structure
[PDB|2HAW] (complex with substrate analogue p-nitrophosphate), [PDB|1WPM] [pubmed|17095506]
[AF|P37487]
Modification
S-cysteinylation after diamide stress (C158) [Pubmed|17611193]
Cys158 is S-bacillithiolated by NaOCl stress in B. subtilis and other Bacillus species [Pubmed|21749987] [Pubmed|21749987]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Additional information
belongs to the 100 most abundant proteins [PubMed|15378759]
Expression and Regulation
Operons
genes
[gene|AE44787B3EB8EF5811B5C447BE2012EC36547B0A|ppaC]
description
[Pubmed|22383849]
Biological materials
Mutant
MGNA-B837 (yybQ::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1836 NBRP B. subtilis, Japan]
References
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Time of last update: 2025-01-20 04:42:02
Author of last update: Jstuelk