ppaC

ppaC
168

inorganic pyrophosphatase

locus
BSU_40550
Molecular weight
33.83 kDa
pI
4.51
Protein length
Gene length
function
recovery of phosphate ions from pyrophosphate
product
inorganic pyrophosphatase
essential
yes
ec
3.6.1.1
synonyms
ppaC, yybQ

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1227 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
4,168,204 4,169,133
Phenotypes of a mutant
essential [Pubmed|12682299]
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The protein
Catalyzed reaction/ biological activity
diphosphate + H2O --> H+ + 2 phosphate (according to UniProt)
Protein family
PPase class C family (single member, according to UniProt)
[wiki|Domains]
[wiki|DHH-DHHA1 domain]
[wiki|Cofactors]
Mn2+ [pubmed|17095506]
Structure
[PDB|2HAW] (complex with substrate analogue p-nitrophosphate), [PDB|1WPM] [pubmed|17095506]
[AF|P37487]
Modification
S-cysteinylation after diamide stress (C158) [Pubmed|17611193]
Cys158 is S-bacillithiolated by NaOCl stress in B. subtilis and other Bacillus species [Pubmed|21749987] [Pubmed|21749987]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Additional information
belongs to the 100 most abundant proteins [PubMed|15378759]
Expression and Regulation
Operons
genes
[gene|AE44787B3EB8EF5811B5C447BE2012EC36547B0A|ppaC]
description
[Pubmed|22383849]
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[gene|AE44787B3EB8EF5811B5C447BE2012EC36547B0A|ppaC]

2024-05-14 21:45:41

ghost

94

fcd43ca793c3486a825abbc00181018ac52e3ac8

258CFB2719165018458171A538329ED5E6856B8F

Biological materials
Mutant
MGNA-B837 (yybQ::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1836 NBRP B. subtilis, Japan]
References
22938038,21749987,15533045,17611193,9845334,9782505,11342544,9633597,15378759,22383849,25733611,17095506

AE44787B3EB8EF5811B5C447BE2012EC36547B0A

Page visits: 4928

Time of last update: 2024-05-22 11:28:30

Author of last update: Jstuelk