sipV

sipV
168

signal peptidase I

locus
BSU_10490
Molecular weight
18.81 kDa
pI
10.12
Protein length
Gene length
function
protein secretion
product
signal peptidase I
essential
no
synonyms
sipV, yhjF

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0681 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,122,175  1,122,681
The protein
Catalyzed reaction/ biological activity
Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins (according to UniProt)
Protein family
[wiki|peptidase S26 family] (according to Uniprot)
Structure
[PDB|4NV4] (from B. anthracis, 47% identity)
[AF|O07560]
Paralogous protein(s)
[protein|C2EAE417DB9250B88BB0E25D4AE760BDE82EFD86|sipT], [protein|CDC6971F39F3EEAAE912CB1402EE1BD64D5A12A0|sipS], [protein|9824F9CF9C2028AF267AC43FE7FD8590E8231AB8|sipU]
[wiki|Localization]
cell membrane (according to UniProt)
Expression and Regulation
Operons
genes
[gene|020DBB58794BF6C450E9A654719E62B2D3B10F04|yhjE]-[gene|ADEEA5E15C100C1DC6E129B9A3E6DECAFCA8C409|sipV]
description
[Pubmed|22383849]
regulation
induced upon DNA damage ([protein|D267AF38B0CF107042326E9B8F3DD3C9C85840E4|lexA]) [Pubmed|16267290]
regulatory mechanism
[protein|D267AF38B0CF107042326E9B8F3DD3C9C85840E4|lexA]: repression, [Pubmed|16267290], in [regulon|protein:D267AF38B0CF107042326E9B8F3DD3C9C85840E4|lexA regulon]
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[gene|020DBB58794BF6C450E9A654719E62B2D3B10F04|yhjE]→[gene|ADEEA5E15C100C1DC6E129B9A3E6DECAFCA8C409|sipV]

2024-08-27 17:10:46

Jstuelk

65

fc8b7e81e7d18b9b493e11b8a6d0ef160dd1bcf5

70E73436169583754454CA49103BB5318623E4A3

Biological materials
Mutant
BKE10490 ([gene|ADEEA5E15C100C1DC6E129B9A3E6DECAFCA8C409|sipV]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE10490 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATGTTACTGTCTCCCTCCA,  downstream forward: _UP4_TAAAAAGACGCTAATTGAAG
BKK10490 ([gene|ADEEA5E15C100C1DC6E129B9A3E6DECAFCA8C409|sipV]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK10490 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATGTTACTGTCTCCCTCCA,  downstream forward: _UP4_TAAAAAGACGCTAATTGAAG
labs
[wiki|Jan Maarten van Dijl], Groningen, Netherlands
References
Reviews
22688815,34410368
Original Publications
9325333,9694797,16267290,28088521

ADEEA5E15C100C1DC6E129B9A3E6DECAFCA8C409

Page visits: 2170

Time of last update: 2024-10-12 01:30:06

Author of last update: Jstuelk