sipV
168
signal peptidase I
locus
BSU_10490
Molecular weight
18.81 kDa
pI
10.12
function
protein secretion
product
signal peptidase I
essential
no
synonyms
sipV, yhjF
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0681 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,122,175 1,122,681
The protein
Catalyzed reaction/ biological activity
Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins (according to UniProt)
Protein family
[wiki|peptidase S26 family] (according to Uniprot)
Structure
[PDB|4NV4] (from B. anthracis, 47% identity)
[AF|O07560]
Paralogous protein(s)
[protein|C2EAE417DB9250B88BB0E25D4AE760BDE82EFD86|sipT], [protein|CDC6971F39F3EEAAE912CB1402EE1BD64D5A12A0|sipS], [protein|9824F9CF9C2028AF267AC43FE7FD8590E8231AB8|sipU]
[wiki|Localization]
cell membrane (according to UniProt)
Expression and Regulation
Operons
genes
[gene|020DBB58794BF6C450E9A654719E62B2D3B10F04|yhjE]-[gene|ADEEA5E15C100C1DC6E129B9A3E6DECAFCA8C409|sipV]
description
[Pubmed|22383849]
regulation
induced upon DNA damage ([protein|D267AF38B0CF107042326E9B8F3DD3C9C85840E4|lexA]) [Pubmed|16267290]
regulatory mechanism
[protein|D267AF38B0CF107042326E9B8F3DD3C9C85840E4|lexA]: repression, [Pubmed|16267290], in [regulon|protein:D267AF38B0CF107042326E9B8F3DD3C9C85840E4|lexA regulon]
Biological materials
Mutant
BKE10490 ([gene|ADEEA5E15C100C1DC6E129B9A3E6DECAFCA8C409|sipV]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE10490 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTTACTGTCTCCCTCCA, downstream forward: _UP4_TAAAAAGACGCTAATTGAAG
BKK10490 ([gene|ADEEA5E15C100C1DC6E129B9A3E6DECAFCA8C409|sipV]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK10490 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTTACTGTCTCCCTCCA, downstream forward: _UP4_TAAAAAGACGCTAATTGAAG
labs
[wiki|Jan Maarten van Dijl], Groningen, Netherlands
References
Reviews
Original Publications
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Time of last update: 2024-12-31 01:15:42
Author of last update: Jstuelk