yktC
168
inositol monophosphatase and 5'-nucleotidase with preference for GMP and IMP
locus
BSU_14670
Molecular weight
29.61 kDa
pI
5.09
function
unknown
product
nucleotidase
essential
no
ec
3.1.3.25
synonyms
yktC, suhB
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0483 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,537,441 1,538,238
Phenotypes of a mutant
sensitive to diamide stress [Pubmed|27784292]
The protein
Catalyzed reaction/ biological activity
myo-inositol phosphate + H2O --> myo-inositol + phosphate (according to UniProt)
Protein family
inositol monophosphatase superfamily (single member, according to UniProt)
Structure
[PDB|5I3S] (from Staphylococcus aureus, 51% identity)
[AF|Q45499]
Expression and Regulation
Operons
genes
[gene|AD151804FC145854DB6BAA12CD52758FB1C3882F|yktC]-[gene|A313B197D6D885EEE7F739E1F137794A8E3AD8F9|ykzC]
description
[pubmed|22383849]
sigma factors
[protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB]: sigma factor, [Pubmed|26577401], in [regulon|protein:580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB regulon]
Biological materials
Mutant
MGNA-A908 (yktC::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/908 NBRP B. subtilis, Japan]
BKE14670 ([gene|AD151804FC145854DB6BAA12CD52758FB1C3882F|yktC]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE14670 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTCGTTCGTACCTCTCTT, downstream forward: _UP4_TAGGCCATTTGAGCAGGATG
BKK14670 ([gene|AD151804FC145854DB6BAA12CD52758FB1C3882F|yktC]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK14670 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTCGTTCGTACCTCTCTT, downstream forward: _UP4_TAGGCCATTTGAGCAGGATG
References
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Time of last update: 2024-10-10 20:24:57
Author of last update: Melvin.boenninger