sppA
168
protease, promotes resistance to antimicrobial peptides
locus
BSU_29530
Molecular weight
36.52 kDa
pI
7.31
function
resistance to lantibiotics
product
protease
essential
no
ec
null
synonyms
sppA, yteI
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0616 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,020,040 3,021,047
Phenotypes of a mutant
more sensitive to lantibiotics such as nisin and subtilin [Pubmed|33028682,23980836]
reduced long-term survival [pubmed|33028682]
The protein
Catalyzed reaction/ biological activity
serine protease that functions to cleave the remnant signal peptides left behind after [wiki|protein secretion] and cleavage by signal peptidases
Protein family
peptidase S49 family (single member, according to UniProt)
Structure
[PDB|3RST] [Pubmed|22472423]
[AF|O34525]
[wiki|Localization]
cell membrane [Pubmed|33028682,22472423]
Expression and Regulation
Operons
genes
[gene|ACB7F015027A83C5D3457818A71B6F47192CEFBE|sppA]-[gene|618337D9BCD1586C5874746D1001DA3A2724E57C|sppI]
description
[Pubmed|9987136]
regulation
induced in response to cell wall stress ([protein|search|SigW]) [Pubmed|12207695]
sigma factors
[protein|3D974DD2967C7F8FD4E3C2AF42617B8AE9F0296D|sigW]: sigma factor, [Pubmed|9987136,12207695], in [regulon|protein:3D974DD2967C7F8FD4E3C2AF42617B8AE9F0296D|sigW regulon]
additional information
self-processes its own C-termini [PubMed|24228759]
Biological materials
Mutant
MGNA-A005 (yteI::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/5 NBRP B. subtilis, Japan]
BKE29530 ([gene|ACB7F015027A83C5D3457818A71B6F47192CEFBE|sppA]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE29530 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTTTTCTCCTCCTTTTT, downstream forward: _UP4_TATGCGAAGTAGGAGGGAAC
BKK29530 ([gene|ACB7F015027A83C5D3457818A71B6F47192CEFBE|sppA]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK29530 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTTTTCTCCTCCTTTTT, downstream forward: _UP4_TATGCGAAGTAGGAGGGAAC
References
Reviews
Original Publications
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Time of last update: 2024-12-21 00:30:04
Author of last update: Jstuelk