mhqO
168
hydroquinone-specific dioxygenase, confers resistence to methyl-hydroxyquinone
locus
BSU_05490
Molecular weight
34.90 kDa
pI
4.83
function
resistence to methyl-hydroxyquinone
product
hydroquinone-specific dioxygenase
essential
no
synonyms
mhqO, ydfO
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0346 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
597,114 598,052
The protein
Protein family
[wiki|extradiol ring-cleavage dioxygenase family] (according to UniProt)
[wiki|Domains]
2 [wiki|VOC domain]s (aa 7-131, aa 152-269) (according to UniProt)
Structure
[PDB|3OAJ]
[AF|P96693]
Paralogous protein(s)
[protein|7334017333600B876030056BE9247AD4E8996A1D|mhqA], [protein|A1CB3DCF2EC78B9B0585CA6AC6F5BB37B8AF0208|mhqE]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|ACAFB2072E74CC059B492A31EF492028B96C569F|mhqO]-[gene|B4384C8C0874BAA7822E9B6DCAB57790018271D8|mhqP]
description
[Pubmed|11532142]
regulation
induced by catechol and 2-methylhydroquinone ([protein|search|MhqR]) [Pubmed|17725564]
regulatory mechanism
[protein|997B828A99D6D8460712C18ED0CE566B285C22DC|mhqR]: repression, [Pubmed|17725564], in [regulon|protein:997B828A99D6D8460712C18ED0CE566B285C22DC|mhqR regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|17725564], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
[protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB]: sigma factor, [Pubmed|11532142], in [regulon|protein:580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB regulon]
genes
[gene|A0842DD5F1B13AC15C95F18751E7836DF31B262A|mhqN]-[gene|ACAFB2072E74CC059B492A31EF492028B96C569F|mhqO]-[gene|B4384C8C0874BAA7822E9B6DCAB57790018271D8|mhqP]
description
[Pubmed|17725564]
regulation
induced by catechol and 2-methylhydroquinone ([protein|search|MhqR]) [Pubmed|17725564]
regulatory mechanism
[protein|997B828A99D6D8460712C18ED0CE566B285C22DC|mhqR]: repression, [Pubmed|17725564], in [regulon|protein:997B828A99D6D8460712C18ED0CE566B285C22DC|mhqR regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|17725564], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Biological materials
Mutant
MGNA-C154 (ydfO::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2152 NBRP B. subtilis, Japan]
BKE05490 ([gene|ACAFB2072E74CC059B492A31EF492028B96C569F|mhqO]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE05490 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TTTAGCCATTTTTATCCGCT, downstream forward: _UP4_TGATTTGACACATAAAAAAT
BKK05490 ([gene|ACAFB2072E74CC059B492A31EF492028B96C569F|mhqO]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK05490 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TTTAGCCATTTTTATCCGCT, downstream forward: _UP4_TGATTTGACACATAAAAAAT
References
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Time of last update: 2024-12-22 02:47:12
Author of last update: Melvin.boenninger