nadD
168
nicotinamide-nucleotide adenylyltransferase
locus
BSU_25640
Molecular weight
22.01 kDa
pI
5.12
function
NAD biosynthesis
product
nicotinamide-nucleotide adenylyltransferase
essential
yes
ec
2.7.7.18
synonyms
nadD, yqeJ
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1057 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,643,765 2,644,334
Phenotypes of a mutant
essential [Pubmed|12682299]
The protein
Catalyzed reaction/ biological activity
ATP + H+ + nicotinate β-D-ribonucleotide --> deamido-NAD+ + diphosphate (according to UniProt)
Protein family
nadD family (single member, according to UniProt)
Structure
[PDB|1KAQ]
[AF|P54455]
Additional information
in some organisms [protein|AA4BB1F5B58371D536A6BBA86F6ECB5E5BFB12A8|nadD] and [protein|247C47AC70A0EA53E625871D9BC463A06E6B05FB|yqeK] form one fused protein [pubmed|35862786]
Expression and Regulation
Operons
genes
[gene|722FD63050EED803C859FFD61338C02D5BB4CC1C|pgpP]-[gene|959C0ED7B9DA50F0EADCF1565405B878D36DA206|yqeH]-[gene|776D79C45DADA631D4A75B0773CFF471A87D9EEC|aroD]-[gene|7774FC36BAEAD33EDD48CB77DA0B5E7E0EA38CA2|yqeI]-[gene|AA4BB1F5B58371D536A6BBA86F6ECB5E5BFB12A8|nadD]-[gene|247C47AC70A0EA53E625871D9BC463A06E6B05FB|yqeK]-[gene|B9D5E9B566D28423232C1A28C966CDEA0E5A6B78|yqeL]-[gene|7F63251ABC07F6C11C57B62CBB948240B08D0181|yqeM]
description
[Pubmed|22383849]
expression
expression is increased upon depletion of depletion of tRNA maturation factors [gene|57A79AAF00243B5E058FA901D43AA7B55CA33F63|rnpB] or [gene|C40C5D35ED53D343C8200248FCCB010BAB388054|rnz] [pubmed|36840557]
Biological materials
Mutant
MGNA-C501 (yqeJ::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2499 NBRP B. subtilis, Japan]
References
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Time of last update: 2025-04-11 13:15:16
Author of last update: Jstuelk