psdS
168
two-component sensor kinase, control of [gene|464DD1855E6B3195EE242637612A16C73FF32FC0|psdA]-[gene|AC7F08DC1DF7DD2F9AFF84041D357B286B1244AC|psdB] in response to lipid II-binding lantibiotics, such as nisin and gallidermin
locus
BSU_34710
Molecular weight
40.02 kDa
pI
7.36
function
resistance against toxic peptides
product
two-component sensor kinase
essential
no
synonyms
psdS, yvcQ
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0642 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,566,358 3,567,428
The protein
Catalyzed reaction/ biological activity
autophosphorylation, phosphorylation of [protein|985E7F25C809AA5DF372101E64960DF704EED53F|psdR]
ATP + protein L-histidine --> ADP + protein N-phospho-L-histidine (according to UniProt)
[wiki|Domains]
two transmembrane segments
[wiki|Histidine kinase domain] (aa 133-349) (according to UniProt)
Structure
[PDB|4I5S] (from Streptococcus mutans, the C-terminal histidine phosphotransferase domain, 29% identity) [pubmed|23468592]
[AF|O06979]
Modification
autophosphorylation on a His residue
[wiki|Localization]
cell membrane (according to UniProt)
Expression and Regulation
Operons
genes
[gene|985E7F25C809AA5DF372101E64960DF704EED53F|psdR]-[gene|A9525886E911164BDFF0A55DA9F5FDD1C1B7A3B6|psdS]-[gene|464DD1855E6B3195EE242637612A16C73FF32FC0|psdA]-[gene|AC7F08DC1DF7DD2F9AFF84041D357B286B1244AC|psdB]
description
[Pubmed|21078927]
regulation
''[protein|search|psdA]'': induced by nisin, gallidermin ([protein|search|PsdR]) [Pubmed|21078927]
regulatory mechanism
[protein|985E7F25C809AA5DF372101E64960DF704EED53F|psdR]: activation, [Pubmed|21078927], in [regulon|protein:985E7F25C809AA5DF372101E64960DF704EED53F|psdR regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|21078927], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Biological materials
Mutant
MGNA-B636 (yvcQ::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1635 NBRP B. subtilis, Japan]
BKE34710 ([gene|A9525886E911164BDFF0A55DA9F5FDD1C1B7A3B6|psdS]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE34710 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TAAGCGGTCGATGAGATAAG, downstream forward: _UP4_TAAGATTGGGGAGCGGAATT
BKK34710 ([gene|A9525886E911164BDFF0A55DA9F5FDD1C1B7A3B6|psdS]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK34710 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TAAGCGGTCGATGAGATAAG, downstream forward: _UP4_TAAGATTGGGGAGCGGAATT
References
Reviews
Original Publications
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Time of last update: 2024-12-22 09:36:08
Author of last update: Jstuelk