upp
168
uracil phosphoribosyltransferase
locus
BSU_36890
Molecular weight
22.89 kDa
pI
5.86
function
UMP synthesis
product
uracil phosphoribosyltransferase
essential
no
ec
2.4.2.9
synonyms
upp, ipc-35d
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0035 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,788,426 3,789,055
The protein
Catalyzed reaction/ biological activity
diphosphate + UMP --> 5-phospho-α-D-ribose 1-diphosphate + uracil (according to UniProt)
Protein family
UPRTase family (single member, according to UniProt)
Structure
[PDB|2EHJ] (from ''Escherichia coli'', 52% identity, 73% similarity)
[AF|P39149]
Expression and Regulation
Operons
Biological materials
Mutant
1A832 (no resistance), [Pubmed|12366828], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A832&Search=1A832 BGSC]
BKE36890 ([gene|A92A17CAE2EF33C320B958325F9728EA0FD98F85|upp]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE36890 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATACTGTGTTTCAGCTCCT, downstream forward: _UP4_TAAAAAATGAAATCCCCAAA
BKK36890 ([gene|A92A17CAE2EF33C320B958325F9728EA0FD98F85|upp]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK36890 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATACTGTGTTTCAGCTCCT, downstream forward: _UP4_TAAAAAATGAAATCCCCAAA
References
Page visits: 2525
Time of last update: 2024-12-25 13:57:47
Author of last update: Jstuelk