nhaC
168
Na /H antiporter
locus
BSU_09680
Molecular weight
47.89 kDa
pI
7.87
function
pH homeostasis
product
Na /H antiporter
essential
no
synonyms
nhaC, yheL
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1757 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,042,885 1,044,246
The protein
Protein family
NhaC Na(+)/H(+) (TC 2.A.35) antiporter family (with [protein|49DF23B8E19658DB32835B6D23DD21E4BF481B20|mleN], according to UniProt)
Structure
[AF|O07553]
Paralogous protein(s)
[protein|49DF23B8E19658DB32835B6D23DD21E4BF481B20|mleN]
[wiki|Localization]
cell membrane (according to UniProt)
Expression and Regulation
Operons
genes
[gene|A7F1B4C0D32E18773170BFBEEB94E5EF55C7DB97|nhaC]
description
[Pubmed|21815947]
regulation
subject to indirect positive regulation by [protein|search|CodY] [Pubmed|24843172]
regulatory mechanism
[protein|D0BBFE1706429A98B7E93998794061A112FE8ECA|nhaX]: activation, (probably) [Pubmed|11274110], in [regulon|protein:D0BBFE1706429A98B7E93998794061A112FE8ECA|nhaX regulon]
additional information
the mRNA is substantially stabilized upon depletion of [gene|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] [PubMed|21815947]
Biological materials
Mutant
MGNA-A707 (yheL::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/707 NBRP B. subtilis, Japan]
BKE09680 ([gene|A7F1B4C0D32E18773170BFBEEB94E5EF55C7DB97|nhaC]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE09680 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAAATAACACCCCATATTT, downstream forward: _UP4_TAAAAAGAGCCCCGCTGTAA
BKK09680 ([gene|A7F1B4C0D32E18773170BFBEEB94E5EF55C7DB97|nhaC]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK09680 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAAATAACACCCCATATTT, downstream forward: _UP4_TAAAAAGAGCCCCGCTGTAA
References
Reviews
Original Publications
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Time of last update: 2024-12-26 16:55:57
Author of last update: Melvin.boenninger