scoA
168
succinyl CoA:3-oxoacid CoA-transferase (subunit A)
locus
BSU_38990
Molecular weight
25.25 kDa
pI
6.61
function
3-hydroxybutyrate utilization
product
succinyl CoA:3-oxoacid CoA-transferase (subunit A)
essential
no
ec
2.8.3.5
synonyms
scoA, yxjD
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1788 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
4,001,976 4,002,692
The protein
Catalyzed reaction/ biological activity
3-oxo acid + succinyl-CoA --> 3-oxoacyl-CoA + succinate (according to UniProt)
Protein family
3-oxoacid CoA-transferase subunit A family (with [protein|D8A050BF150C6E5B910C24C0E023F0829EC95BAD|yodS], according to UniProt)
Structure
[PDB|3CDK] (the [protein|A7E61C3D12BBDDD3EFD65B1EDBE280497D7B6CD0|scoA]-[protein|7F46EDA8F1EB8D9817C62D7D361FF32F9CD814AD|scoB] complex)
[AF|P42315]
Paralogous protein(s)
[protein|D8A050BF150C6E5B910C24C0E023F0829EC95BAD|yodS]
Expression and Regulation
Operons
genes
[gene|B416BB368A96926526458B2258BF8AB928D7C15E|hbuT]-[gene|A7E61C3D12BBDDD3EFD65B1EDBE280497D7B6CD0|scoA]-[gene|7F46EDA8F1EB8D9817C62D7D361FF32F9CD814AD|scoB]-[gene|B7B1D28E50244704324920E5A6F110DA8D63F6C0|yxjF]
description
[Pubmed|10746760]
regulation
expressed early during sporulation in the mother cell ([protein|search|SigE]) [Pubmed|12662922]
regulatory mechanism
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: repression, [Pubmed|12850135,10666464], in [regulon|protein:E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA regulon]
sigma factors
[protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE]: sigma factor, [Pubmed|12662922], in [regulon|protein:3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE regulon]
Biological materials
Mutant
MGNA-B728 (yxjD::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1727 NBRP B. subtilis, Japan]
BKE38990 ([gene|A7E61C3D12BBDDD3EFD65B1EDBE280497D7B6CD0|scoA]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE38990 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATTGATGCCCCTTTCGT, downstream forward: _UP4_GCATCGGGAAAGGGTGAGGC
BKK38990 ([gene|A7E61C3D12BBDDD3EFD65B1EDBE280497D7B6CD0|scoA]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK38990 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATTGATGCCCCTTTCGT, downstream forward: _UP4_GCATCGGGAAAGGGTGAGGC
References
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Time of last update: 2024-12-20 02:39:18
Author of last update: Melvin.boenninger