mraZ
168
transcription repressor of the [gene|A7131ACFA0CF5C222237C76E502D4AAD1F9BA3E4|mraZ]-[gene|1F894D6895CE13AA006CFE13A702E46C568F6E79|rsmH]-[gene|79712F4CF884A660C71B45B3397AEFA5C0AFA683|ftsL]-[gene|EBEFF9E0A524DCDA19382E5401B923B805E4C559|pbpB] operon
locus
BSU_15130
Molecular weight
16.43 kDa
pI
4.97
function
control of cell division gene expression
product
transcription repressor of the [gene|A7131ACFA0CF5C222237C76E502D4AAD1F9BA3E4|mraZ]-[gene|1F894D6895CE13AA006CFE13A702E46C568F6E79|rsmH]-[gene|79712F4CF884A660C71B45B3397AEFA5C0AFA683|ftsL]-[gene|EBEFF9E0A524DCDA19382E5401B923B805E4C559|pbpB] operon
essential
no
ec
null
synonyms
mraZ, yllB
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG2001 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,580,121 1,580,552
Phenotypes of a mutant
overexpression results in lethal filamentation (due to repression of the own operon, can be rescued by constitutive expression of [protein|79712F4CF884A660C71B45B3397AEFA5C0AFA683|ftsL]) [pubmed|35943250]
The protein
Protein family
mraZ family (single member, according to UniProt)
[wiki|Domains]
2 [wiki|SpoVT-AbrB domain]s (aa 7-47, aa 76-119) (according to UniProt)
Structure
[PDB|1N0G] (the homolog from ''Mycoplasma pneumoniae'') [Pubmed|15146477]
[AF|P55343]
[wiki|Localization]
nucleoid (heterogeneous) [Pubmed|16479537]
Expression and Regulation
Operons
genes
[gene|A7131ACFA0CF5C222237C76E502D4AAD1F9BA3E4|mraZ]-[gene|1F894D6895CE13AA006CFE13A702E46C568F6E79|rsmH]-[gene|79712F4CF884A660C71B45B3397AEFA5C0AFA683|ftsL]-[gene|EBEFF9E0A524DCDA19382E5401B923B805E4C559|pbpB]
description
[Pubmed|8636036,8244929]
regulation
constitutively expressed [Pubmed|15758244]
Biological materials
Mutant
MGNA-B129 (yllB::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1128 NBRP B. subtilis, Japan]
1A817 ( ''mraZ''::''erm''), [Pubmed|12682299], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A817&Search=1A817 BGSC]
BKE15130 ([gene|A7131ACFA0CF5C222237C76E502D4AAD1F9BA3E4|mraZ]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE15130 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGATCTCTTGCCCCACTT, downstream forward: _UP4_TAATGATTCTTCGTGTATAA
BKK15130 ([gene|A7131ACFA0CF5C222237C76E502D4AAD1F9BA3E4|mraZ]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK15130 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGATCTCTTGCCCCACTT, downstream forward: _UP4_TAATGATTCTTCGTGTATAA
References
Reviews
Original Publications
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Time of last update: 2024-11-02 23:51:44
Author of last update: Jstuelk