mraZ

mraZ
168

transcription repressor of the [gene|A7131ACFA0CF5C222237C76E502D4AAD1F9BA3E4|mraZ]-[gene|1F894D6895CE13AA006CFE13A702E46C568F6E79|rsmH]-[gene|79712F4CF884A660C71B45B3397AEFA5C0AFA683|ftsL]-[gene|EBEFF9E0A524DCDA19382E5401B923B805E4C559|pbpB] operon

locus
BSU_15130
Molecular weight
16.43 kDa
pI
4.97
Protein length
Gene length
function
control of cell division gene expression
product
transcription repressor of the [gene|A7131ACFA0CF5C222237C76E502D4AAD1F9BA3E4|mraZ]-[gene|1F894D6895CE13AA006CFE13A702E46C568F6E79|rsmH]-[gene|79712F4CF884A660C71B45B3397AEFA5C0AFA683|ftsL]-[gene|EBEFF9E0A524DCDA19382E5401B923B805E4C559|pbpB] operon
essential
no
ec
null
synonyms
mraZ, yllB

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG2001 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,580,121  1,580,552
Phenotypes of a mutant
overexpression results in lethal filamentation (due to repression of the own operon, can be rescued by constitutive expression of [protein|79712F4CF884A660C71B45B3397AEFA5C0AFA683|ftsL]) [pubmed|35943250]
The protein
Protein family
mraZ family (single member, according to UniProt)
[wiki|Domains]
2 [wiki|SpoVT-AbrB domain]s (aa 7-47, aa 76-119) (according to UniProt)
Structure
[PDB|1N0G] (the homolog from ''Mycoplasma pneumoniae'') [Pubmed|15146477]
[AF|P55343]
[wiki|Localization]
nucleoid (heterogeneous) [Pubmed|16479537]
Expression and Regulation
Operons
genes
[gene|A7131ACFA0CF5C222237C76E502D4AAD1F9BA3E4|mraZ]-[gene|1F894D6895CE13AA006CFE13A702E46C568F6E79|rsmH]-[gene|79712F4CF884A660C71B45B3397AEFA5C0AFA683|ftsL]-[gene|EBEFF9E0A524DCDA19382E5401B923B805E4C559|pbpB]
description
[Pubmed|8636036,8244929]
regulation
constitutively expressed [Pubmed|15758244]
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[gene|A7131ACFA0CF5C222237C76E502D4AAD1F9BA3E4|mraZ]→[gene|EBEFF9E0A524DCDA19382E5401B923B805E4C559|pbpB]

2024-11-02 19:39:23

Jstuelk

111

d5321fe6b1e9387ca670f35171261c39867c1f3d

9D42077BFFD1B3A740698D26FB54D7B31E3FD0C7

Biological materials
Mutant
MGNA-B129 (yllB::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1128 NBRP B. subtilis, Japan]
1A817 ( ''mraZ''::''erm''), [Pubmed|12682299], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A817&Search=1A817 BGSC]
BKE15130 ([gene|A7131ACFA0CF5C222237C76E502D4AAD1F9BA3E4|mraZ]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE15130 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATGATCTCTTGCCCCACTT,  downstream forward: _UP4_TAATGATTCTTCGTGTATAA
BKK15130 ([gene|A7131ACFA0CF5C222237C76E502D4AAD1F9BA3E4|mraZ]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK15130 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATGATCTCTTGCCCCACTT,  downstream forward: _UP4_TAATGATTCTTCGTGTATAA
References
Reviews
36411352
Original Publications
8636036,16479537,8244929,16511046,15146477,35943250

A7131ACFA0CF5C222237C76E502D4AAD1F9BA3E4

Page visits: 3401

Time of last update: 2024-11-02 23:51:44

Author of last update: Jstuelk