capA

capA
168

gamma-polyglutamate transporter,capsular polyglutamate biosynthesis, involved in controlling the D/L enantiomer ratio in polyglutamate

locus
BSU_35880
Molecular weight
42.60 kDa
pI
9.27
Protein length
380 aaSequenceBlast
Gene length
1143 bpSequenceBlast
function
capsular polyglutamate biosynthesis
product
gamma-polyglutamate transporter
essential
no
synonyms
capA, ywtB, pgsA
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG2843 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,697,821  3,698,963
The protein
Protein family
CapA family (with [protein|8DCA50478136628DD9E5D01E89609A686EED9F57|tkmA] and [protein|F6C4634BF871D9A01E27014FFED7527C54BF560D|epsA], according to UniProt)
Structure
[AF|P96738]
Expression and Regulation
Operons
genes
[gene|86C05126ADBA22BB1771B1FA3D214B2E7A36311E|capB]-[gene|D66994D077D1382B88FF65075E44C2A31089548F|capC]-[gene|A696434A086A428D411CAF45B37CD8F82AC2503F|capA]-[gene|6B61DCE8D27776EBF942621D3AE90F410FD13F37|capE]
description
[Pubmed|11751809]
regulatory mechanism
[protein|D343D2096664A972026D911E7A17A35C7B1CD1C9|degU]: activation, [protein|D343D2096664A972026D911E7A17A35C7B1CD1C9|degU]-P, [Pubmed|19734658], in [regulon|protein:D343D2096664A972026D911E7A17A35C7B1CD1C9|degU regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|19420703], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
additional information
expression of the operon is increased in '[protein|search|motA]' or '[protein|search|motB]' mutants due to increased [protein|search|DegU] phosphorylation [PubMed|24296669]
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[gene|86C05126ADBA22BB1771B1FA3D214B2E7A36311E|capB]→[gene|6B61DCE8D27776EBF942621D3AE90F410FD13F37|capE]

2024-11-01 13:00:49

ghost

99

bf6b0bf03353d832d0fb99e09c0c2fcd8af8f057

1302D3190C59C849B9803B3A11C008FA08B67E54

Biological materials
Mutant
MGNA-B121 (pgsA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1120 NBRP B. subtilis, Japan]
BKE35880 ([gene|A696434A086A428D411CAF45B37CD8F82AC2503F|capA]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE35880 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_TTTCATCGTTTGACACACCT,  downstream forward: _UP4_TCTAAATAATCGGAGTGATA
BKK35880 ([gene|A696434A086A428D411CAF45B37CD8F82AC2503F|capA]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK35880 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_TTTCATCGTTTGACACACCT,  downstream forward: _UP4_TCTAAATAATCGGAGTGATA
References
Reviews
20735481,16689787,29215550
Original Publications
36815589,11751809,19420703,16233197,20564357,20564574,24296669,21965392,27073802,29971620,30295732,31837088,16278834

A696434A086A428D411CAF45B37CD8F82AC2503F

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Time of last update: 2024-12-23 08:28:31

Author of last update: Jstuelk