araR
168
transcriptional repressor ([wiki|GntR family], [wiki|LacI family]) of the arabinose utilization genes
locus
BSU_33970
Molecular weight
43.00 kDa
pI
6.34
function
regulation of arabinose utilization
product
transcriptional repressor ([wiki|GntR family], [wiki|LacI family])
essential
no
synonyms
araR, araC, yvbS
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1609 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,485,604 3,486,758
Phenotypes of a mutant
inactivation of ''[gene|A567466894AE9DE7CDE7816615433A37532297B5|araR]'' reduces sporulation efficiency to 28% that of wild type cells [Pubmed|26735940]
The protein
Protein family
[wiki|GntR family]: N-terminal DNA-binding domain, [wiki|LacI family]: C-terminal effector-binding domain
[wiki|Domains]
N-terminal DNA-binding domain ([wiki|GntR family])
C-terminal effector-binding domain ([wiki|LacI family])
[wiki|HTH gntR-type domain] (aa 1-70) (according to UniProt)
Structure
[PDB|3TB6] (effector-binding domain) [Pubmed|22281747]
[AF|P96711]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|A567466894AE9DE7CDE7816615433A37532297B5|araR]
description
[Pubmed|9045819]
regulation
induced by arabinose ([protein|search|AraR]) [Pubmed|10417639]
regulatory mechanism
[protein|A567466894AE9DE7CDE7816615433A37532297B5|araR]: repression, [Pubmed|10417639], in [regulon|protein:A567466894AE9DE7CDE7816615433A37532297B5|araR regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|9401028], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Biological materials
Mutant
BKE33970 ([gene|A567466894AE9DE7CDE7816615433A37532297B5|araR]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE33970 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATCCATTCCTCCAAAAT, downstream forward: _UP4_TAAAAAAAGCAATGTATGGG
BKK33970 ([gene|A567466894AE9DE7CDE7816615433A37532297B5|araR]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK33970 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATCCATTCCTCCAAAAT, downstream forward: _UP4_TAAAAAAAGCAATGTATGGG
References
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Time of last update: 2025-01-04 08:36:58
Author of last update: Jstuelk