hemL
168
glutamate-1-semialdehyde aminotransferase
locus
BSU_28120
Molecular weight
46.29 kDa
pI
5.05
function
heme biosynthesis
product
glutamate-1-semialdehyde aminotransferase
essential
no
ec
5.4.3.8
synonyms
hemL, hemK
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0001 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,872,880 → 2,874,172
The protein
Catalyzed reaction/ biological activity
(S)-4-amino-5-oxopentanoate --> 5-aminolevulinate (according to UniProt)
Protein family
[wiki|Class-III pyridoxal-phosphate-dependent aminotransferase family] (according to UniProt)
[wiki|Cofactors]
PLP (according to UniProt)
Structure
[PDB|3BS8] [Pubmed|20946885]
[AF|P30949]
Paralogous protein(s)
[protein|8BB8EECA8ECFA1CC6D46E81250905DBC6D2C503E|gsaB]
Expression and Regulation
Operons
genes
[gene|B1413EB525000744BE8E429E760220A13BC4530D|hemA]-[gene|88616BA1E853E11BE0CB18F06287CA4C68143148|hemX]-[gene|D266E22E07B849E2AEB0EF232C49A2FE1EA4E02B|hemC]-[gene|33459D4389F85D60311FCE770BBA0ED9802BA342|hemD]-[gene|70263A55987F110209367CF45AD65A584AD3077D|hemB]-[gene|A54B2C86638D474F5F892003B42C535B5B39A42E|hemL]
description
[Pubmed|1672867]
regulation
induced by hydrogen peroxide ([protein|search|PerR]) [Pubmed|11532148]
regulatory mechanism
[protein|00BCAAE16576DC5426A652580C69A570FC7A1C2C|perR]: repression, [Pubmed|11532148], in [regulon|protein:00BCAAE16576DC5426A652580C69A570FC7A1C2C|perR regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|1672867], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Biological materials
Mutant
BKE28120 (Δ[gene|A54B2C86638D474F5F892003B42C535B5B39A42E|hemL]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE28120 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTGCCTCAACTCCTGTC, downstream forward: _UP4_TAAGAGTGAAAACCGGTATC
BKK28120 (Δ[gene|A54B2C86638D474F5F892003B42C535B5B39A42E|hemL]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK28120 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTGCCTCAACTCCTGTC, downstream forward: _UP4_TAAGAGTGAAAACCGGTATC
References
Reviews
Original Publications
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Time of last update: 2024-12-21 16:27:33
Author of last update: Melvin.boenninger