ytcB
168
putative UDP-glucose epimerase
locus
BSU_30870
Molecular weight
34.76 kDa
pI
8.87
function
unknown
product
putative UDP-glucose epimerase
essential
no
synonyms
ytcB
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0451 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,157,008 3,157,958
The protein
Protein family
[wiki|NAD(P)-dependent epimerase/dehydratase family] (according to UniProt)
Structure
[PDB|1SB8] (Pseudomonas aeruginosa UDP-N-acetylglucosamine 4-epimerase, 34% identity) [Pubmed|15016816], [PDB|5U4Q] (from Klebsiella pneumoniae 35% identity)
[AF|O34886]
Paralogous protein(s)
[protein|9836E90BD443F5269A43E5C69FCF2CCB22EDF65B|yfnG], (29,5%)
Expression and Regulation
Operons
genes
[gene|59024C05AA0106719C81E45E3B060A6F710B2690|ytcA]-[gene|A51B5F9F86D2F7B690712B9EC181B1C07B312E02|ytcB]-[gene|6911DFB27F6A23F3775DAC5C289EFA163FBD1E56|ytcC]
description
[Pubmed|22383849]
regulation
expressed late during sporulation in the mother cell ([protein|6FAD8804AA32B84819DDE57C0AF63F208FB9FFD1|sigKC], [wiki|GerE]) [Pubmed|26577401,15699190,12480901]
regulatory mechanism
[protein|19228BAD44E6DA3DE908DC390FDF628C18D94E65|gerE]: repression, [Pubmed|26577401], in [regulon|protein:19228BAD44E6DA3DE908DC390FDF628C18D94E65|gerE regulon]
sigma factors
[protein|24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|sigK]: sigma factor, [Pubmed|22383849,15699190,12480901], in [regulon|protein:24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|sigK regulon]
Biological materials
Mutant
MGNA-A279 (ytcB::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/279 NBRP B. subtilis, Japan]
BKE30870 ([gene|A51B5F9F86D2F7B690712B9EC181B1C07B312E02|ytcB]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE30870 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CGCTGCTCCTGTGACGAGTA, downstream forward: _UP4_TCGCTGTATCAGGGGGAATA
BKK30870 ([gene|A51B5F9F86D2F7B690712B9EC181B1C07B312E02|ytcB]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK30870 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CGCTGCTCCTGTGACGAGTA, downstream forward: _UP4_TCGCTGTATCAGGGGGAATA
References
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Time of last update: 2024-10-10 23:25:25
Author of last update: Jstuelk