ntdB
168
kanosamine-6-phosphate phosphatase
locus
BSU_10540
Molecular weight
33.05 kDa
pI
5.35
function
synthesis of the antibiotic kanosamine
product
kanosamine-6-phosphate phosphatase
essential
no
synonyms
ntdB, yhjK
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0561 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,127,466 1,128,314
The protein
Catalyzed reaction/ biological activity
kanosamine-6-phosphate --> kanosamine [Pubmed|23586652]
Protein family
[wiki|HAD superfamily] (according to UniProt)
[wiki|Cof family] (according to UniProt)
Structure
[PDB|3GYG]
[AF|O07565]
Expression and Regulation
Operons
genes
[gene|2F850E2DFA6287DB3890243803E06FDE7ACDB10E|ntdA]-[gene|A4DE6C394B64813A732255734758403241FFAC2F|ntdB]-[gene|29DAF5343A42EAD8DB97925FE7D049410F7B7FCA|ntdC]-[gene|ADB476B0B385D9B9CAF02902CE115C8309F67911|glcP]
description
[Pubmed|17056753]
regulation
induced by 3,3'-neotrehalosadiamine and kanosamine ([protein|9118A36CD30E7C99697B3659BB04E03BB7EE71D7|ntdR]) [Pubmed|33619155,14612444]
regulatory mechanism
[protein|9118A36CD30E7C99697B3659BB04E03BB7EE71D7|ntdR]: activation , in [regulon|protein:9118A36CD30E7C99697B3659BB04E03BB7EE71D7|ntdR regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|14612444], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Biological materials
Mutant
MGNA-A724 (yhjK::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/724 NBRP B. subtilis, Japan]
BKE10540 ([gene|A4DE6C394B64813A732255734758403241FFAC2F|ntdB]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE10540 BGSC], [Pubmed|28189581], upstream reverse: _UP1_AGGATGTTCAACCGTGGATA, downstream forward: _UP4_ATTGGATCATGAGGAGGAAA
BKK10540 ([gene|A4DE6C394B64813A732255734758403241FFAC2F|ntdB]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK10540 BGSC], [Pubmed|28189581], upstream reverse: _UP1_AGGATGTTCAACCGTGGATA, downstream forward: _UP4_ATTGGATCATGAGGAGGAAA
References
Reviews
Original Publications
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Time of last update: 2025-01-30 13:40:10
Author of last update: Melvin.boenninger