natK
168
two-component sensor kinase, regulation of the [gene|B019FD0CB6F76C03DA5E76ABD1B324BA5E1A6936|natA]-[gene|A8ADA02BBB549866DE330040CF6D06ECC3B00099|natB] operon
locus
BSU_02730
Molecular weight
34.92 kDa
pI
8.05
function
regulation of the [gene|B019FD0CB6F76C03DA5E76ABD1B324BA5E1A6936|natA]-[gene|A8ADA02BBB549866DE330040CF6D06ECC3B00099|natB] operon
product
two-component sensor kinase
essential
no
synonyms
natK, yccG
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG3290 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
294,615 295,571
The protein
Catalyzed reaction/ biological activity
autophosphorylation, phosphorylation of [protein|D3F6337B94A633730E514B05CA852BE9AA3741B3|natR] in response to sodium availability
ATP + protein L-histidine --> ADP + protein N-phospho-L-histidine (according to UniProt)
[wiki|Domains]
three transmembrane segments
[wiki|Histidine kinase domain] (aa 132-318) (according to UniProt)
Structure
[AF|P70954]
Modification
autophosphorylation on a His residue
[wiki|Localization]
cell membrane (according to UniProt)
Expression and Regulation
Operons
genes
[gene|D3F6337B94A633730E514B05CA852BE9AA3741B3|natR]-[gene|A4644CB18F7D0DF3E7E50ABB0C0F224D5744A1A5|natK]
description
[pubmed|22383849]
Biological materials
Mutant
MGNA-C042 (yccG::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2040 NBRP B. subtilis, Japan]
BKE02730 ([gene|A4644CB18F7D0DF3E7E50ABB0C0F224D5744A1A5|natK]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE02730 BGSC], [Pubmed|28189581], upstream reverse: _UP1_AAGGGTAATCACGTACTAAA, downstream forward: _UP4_TAAAAAAACCTTGAAAAGCC
BKK02730 ([gene|A4644CB18F7D0DF3E7E50ABB0C0F224D5744A1A5|natK]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK02730 BGSC], [Pubmed|28189581], upstream reverse: _UP1_AAGGGTAATCACGTACTAAA, downstream forward: _UP4_TAAAAAAACCTTGAAAAGCC
References
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Time of last update: 2024-10-15 18:15:53
Author of last update: Melvin.boenninger