uxaB

uxaB
168

tagaturonate reductase

locus
BSU_12380
Molecular weight
55.19 kDa
pI
5.06
Protein length
Gene length
function
hexuronate utilization
product
tagaturonate reductase
essential
no
ec
1.1.1.58
synonyms
uxaB, yjmI

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0246 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,309,880  1,311,322
The protein
Catalyzed reaction/ biological activity
D-altronate + NAD+ --> keto-D-tagaturonate + NADH (according to UniProt)
Protein family
mannitol dehydrogenase family (with [protein|4D54898D405EA25A0C74B1F02A492143D49B7B07|mtlD], according to UniProt)
Structure
[PDB|4IM7] (YdfI from E. coli, aa 1 - 370, 26% identity)
[AF|O34354]
Expression and Regulation
Operons
genes
[gene|3AEA5D769B89E676C916FD8934D762B4C9A02AA2|yjmC]-[gene|CC55984E31C5698668CCCD4AC6E2210B2B41ACAB|yjmD]-[gene|A0A6D36BEC397345A1D17E6A7C34E1F612FD46C7|uxuA]-[gene|B886E504A767343042DE9BF4E23E6798D124A2CF|yjmF]-[gene|6D08E897DD697523FD0720704A25AD4472075B6C|exuT]-[gene|69B143987DCF73B5D080E3FD87A6CA2940E07DA8|exuR]-[gene|A1C64447E0074B06C9210CC51680273FAAE703FA|uxaB]-[gene|ED29D2DE48AADEA09C90F08B6021555C357946B4|uxaA]
description
[Pubmed|9882655]
regulation
induced by galacturonate ([protein|search|ExuR]) [Pubmed|9882655]
regulatory mechanism
[protein|69B143987DCF73B5D080E3FD87A6CA2940E07DA8|exuR]: repression, in the absence of inducer, in [regulon|protein:69B143987DCF73B5D080E3FD87A6CA2940E07DA8|exuR regulon]
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: repression, [pubmed|9882655] [pubmed|10666464], in [regulon|protein:E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|9882655], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
[protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE]: sigma factor, [Pubmed|15699190,9882655], in [regulon|protein:3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE regulon]
Open in new tab

[gene|3AEA5D769B89E676C916FD8934D762B4C9A02AA2|yjmC]→[gene|ED29D2DE48AADEA09C90F08B6021555C357946B4|uxaA]

2024-10-06 08:05:53

ghost

72

e9b60dda83535baf9252c89c7130d2fdeb844e6f

417675688A3DB0A933113CA632D3321516D969A2

genes
[gene|5A0C29C7E218701727523885D01A48D02266B421|uxaC]-[gene|59CD3E4C24326542D9C85BB6FE64FBF49869EB55|yjmB]-[gene|3AEA5D769B89E676C916FD8934D762B4C9A02AA2|yjmC]-[gene|CC55984E31C5698668CCCD4AC6E2210B2B41ACAB|yjmD]-[gene|A0A6D36BEC397345A1D17E6A7C34E1F612FD46C7|uxuA]-[gene|B886E504A767343042DE9BF4E23E6798D124A2CF|yjmF]-[gene|6D08E897DD697523FD0720704A25AD4472075B6C|exuT]-[gene|69B143987DCF73B5D080E3FD87A6CA2940E07DA8|exuR]-[gene|A1C64447E0074B06C9210CC51680273FAAE703FA|uxaB]-[gene|ED29D2DE48AADEA09C90F08B6021555C357946B4|uxaA]
description
[Pubmed|9882655]
regulation
induced by galacturonate ([protein|search|ExuR]) [Pubmed|9882655]
regulatory mechanism
[protein|69B143987DCF73B5D080E3FD87A6CA2940E07DA8|exuR]: repression, in the absence of inducer, in [regulon|protein:69B143987DCF73B5D080E3FD87A6CA2940E07DA8|exuR regulon]
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: repression, [pubmed|9882655] [pubmed|10666464], in [regulon|protein:E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|9882655], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Open in new tab

[gene|5A0C29C7E218701727523885D01A48D02266B421|uxaC]→[gene|ED29D2DE48AADEA09C90F08B6021555C357946B4|uxaA]

2024-10-06 08:05:33

ghost

74

0325999ea185bfaaf2dea87e1701479c52256033

A15F6E93B04DC8C4B59B7976DAC34CE9AC0B8E51

Biological materials
Mutant
MGNA-A373 (yjmI::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/373 NBRP B. subtilis, Japan]
BKE12380 ([gene|A1C64447E0074B06C9210CC51680273FAAE703FA|uxaB]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE12380 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CACCCTTATTGCCTCCCTCT,  downstream forward: _UP4_TGCATACAAGGGGGAGAGGT
BKK12380 ([gene|A1C64447E0074B06C9210CC51680273FAAE703FA|uxaB]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK12380 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CACCCTTATTGCCTCCCTCT,  downstream forward: _UP4_TGCATACAAGGGGGAGAGGT
References
9579062,9579062,9882655,10666464

A1C64447E0074B06C9210CC51680273FAAE703FA

Page visits: 2691

Time of last update: 2024-10-03 19:35:10

Author of last update: Melvin.boenninger