yfjA

yfjA
168

putative chaperone, essential for the toxic activity of the [protein|F130D13E1F9C03157ECF37C91F90F2487CF22B09|yfjB]-[protein|C832113D9C59F56C6CDA695B589B1E001C881ABE|yfjC] toxin

locus
BSU_08170
Molecular weight
11.89 kDa
pI
4.86
Protein length
Gene length
function
unknown
product
putative chaperone support the [protein|F130D13E1F9C03157ECF37C91F90F2487CF22B09|yfjB]-[protein|C832113D9C59F56C6CDA695B589B1E001C881ABE|yfjC] toxin
essential
no
synonyms
yfjA

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG4842 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
889,372  889,686
The protein
Protein family
WXG100 family (with [protein|50D2A03E2D7B5D461540FD157377E0D37F771888|yukE], according to UniProt) (pfam06013) [Pubmed|11973144]
Structure
[PDB|2VRZ] (from Staphylococcus aureus, 21% identity) [pubmed|18773907]
[AF|O31558]
[wiki|Localization]
secreted, by the type VII [wiki|protein secretion] system [protein|3CC3E197848E9688413C15CEA7DDCF0A7120A920|yukD]-[protein|3FE4A91C7D0B43C8704391F2F9493852B3AED9B0|essB]-[protein|6007664F3D979B4D8D4662C7F6E5CF2F489268E3|yukB]-[protein|0A38B2E900532C9950DE6E629F5EB21D64E18B55|yueB]-[protein|DA52C4CD130F32734E01A52F2F395127D2260F61|yueC] [Pubmed|39436054]
Expression and Regulation
Operons
genes
[gene|A177DF098115F85F23A1D42EFB07D294B515830F|yfjA]-[gene|F130D13E1F9C03157ECF37C91F90F2487CF22B09|yfjB]-[gene|C832113D9C59F56C6CDA695B589B1E001C881ABE|yfjC]-[gene|F18F68234236D28894084695429DBF47AA061BE1|yfjD]-[gene|D0F98493600C1BED7118C83E6079AEF0B0D460FB|yfjE]-[gene|642A9A6770EF067A0EC7F51A08940C330EB3610A|yfjF]
description
[pubmed|22383849]
expression
expressed in the subset of cells that undergoes sporulation [pubmed|39436054]
regulatory mechanism
[protein|D343D2096664A972026D911E7A17A35C7B1CD1C9|degU]: transcription activation, [pubmed|39436054], in [regulon|protein:D343D2096664A972026D911E7A17A35C7B1CD1C9|degU regulon]
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[gene|A177DF098115F85F23A1D42EFB07D294B515830F|yfjA]→[gene|642A9A6770EF067A0EC7F51A08940C330EB3610A|yfjF]

2024-10-31 18:39:51

Jstuelk

78

AC055875C4E039DF08AE568C825D5A55BFDF9629

5CDE782AC458249C2230482A8333E5FD084FF0F2

Biological materials
Mutant
MGNA-C288 (yfjA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2286 NBRP B. subtilis, Japan]
BKE08170 ([gene|A177DF098115F85F23A1D42EFB07D294B515830F|yfjA]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE08170 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CAACTTTTGTCCCCTGCCTT,  downstream forward: _UP4_CATAAACTCGGGAGGTGAAC
BKK08170 ([gene|A177DF098115F85F23A1D42EFB07D294B515830F|yfjA]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK08170 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CAACTTTTGTCCCCTGCCTT,  downstream forward: _UP4_CATAAACTCGGGAGGTGAAC
References
11973144,18773907,39436054,37122534,24828531

A177DF098115F85F23A1D42EFB07D294B515830F

Page visits: 2163

Time of last update: 2024-11-02 06:02:56

Author of last update: Jstuelk