ypgQ
168
Mn2+-dependent pyrophosphohydrolase, hydrolyzes (deoxy)ribonucleoside triphosphate [(d)NTP] to (deoxy)ribonucleoside monophosphate and pyrophosphate
locus
BSU_21890
Molecular weight
22.98 kDa
pI
5.51
function
degradation of excessive or abnormal nucleotides
product
Mn2+-dependent pyrophosphohydrolase
essential
no
synonyms
ypgQ
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1418 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,303,920 2,304,537
The protein
[wiki|Domains]
[wiki|HD domain] (aa 22-138) [Pubmed|27062940]
[wiki|Cofactors]
Mn2+ [Pubmed|27062940]
Structure
[PDB|5IHY] [Pubmed|27062940]
[PDB|5DQV] [Pubmed|27062940]
[PDB|5DQW] (complexed with ADP) [Pubmed|27062940]
[AF|P54168]
Expression and Regulation
Operons
genes
[gene|9929712AC9E5581DD0EF3213CC49A0E6C8D3087D|bsaA]-[gene|A0CC440185318F7F8665AF7A8279C79A09E35518|ypgQ]-[gene|B42367583867799BD88D737C848E16B9143C5957|ypgR]
description
[Pubmed|22383849]
Biological materials
Mutant
MGNA-A888 (ypgQ::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/888 NBRP B. subtilis, Japan]
BKE21890 ([gene|A0CC440185318F7F8665AF7A8279C79A09E35518|ypgQ]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE21890 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TTCCTTCACAAAAACACCCT, downstream forward: _UP4_TAATAGAAGGCTTGGAGCGA
BKK21890 ([gene|A0CC440185318F7F8665AF7A8279C79A09E35518|ypgQ]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK21890 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TTCCTTCACAAAAACACCCT, downstream forward: _UP4_TAATAGAAGGCTTGGAGCGA
References
Page visits: 1977
Time of last update: 2024-12-26 05:34:18
Author of last update: Melvin.boenninger