bdbC
168
thiol-disulfide oxidoreductase, required for the formation of thiol disulfide bonds in several proteins
locus
BSU_33470
Molecular weight
15.57 kDa
pI
9.05
function
oxidative folding of proteins
product
thiol-disulfide oxidoreductase
essential
no
ec
null
synonyms
bdbC, yvgU
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1495 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,437,644 3,438,060
Phenotypes of a mutant
loss of transformability [Pubmed|11744713]
sensitive to osmotic shock [Pubmed|22540663]
several proteins are absent from the membrane proteome of a ''[gene|A01637E1BFABA20A2923BA85A25CCD8A0D665F78|bdbC]-[gene|CED818CEF5B573A40F382157375E60C0B331F098|bdbD]'' mutant: [Pubmed|22540663]
the membrane proteins [protein|35E6C81BE481C3E57CF47B781580368C3AC15D83|bglP], [protein|EC287BBD7AB1EB44A33BF29144448F53D06AC6D9|tcyP], [protein|9824F9CF9C2028AF267AC43FE7FD8590E8231AB8|sipU], [protein|497C9654DC7514FF738D18E1F083299C43003A4C|lytA], and [protein|573EBCDC59BB0167F79F00D87B916843031048D8|yxaI] [Pubmed|22540663]
the cytoplasmic or membrane-associated proteins [protein|search|GlkX], [protein|1629A875FCCA0C0EB1C959ED31BB6B3CFA839BF9|proA], [protein|E7741ED6F15044900BDC5F0584246469D2D4D586|pyrAA], [protein|D57DC8A53E52BC4A2EA894E3C9FD983592882918|pyrAB], [protein|40655595D0C573B4CB75FB255CBB01A6ACF1F94D|pyrH], [protein|0197A037D2AF049B295E1DA60187D4614B2BAC51|pyrE], [protein|5D0D0D2413377FCA92440334E92B5A27A5963D9E|pyrF], [protein|047CE33C0CC127DAD15D68D63843DF89F93ED3BF|degS], [protein|D8637043C7E2291589C966E95F94DC61B1A8AB75|ecfA1] [Pubmed|22540663]
The protein
Catalyzed reaction/ biological activity
formation of thiol disulfide bonds in [protein|363C6FE07C5E56FDE6BEC6ACFBA1A5535F0F64AC|comEC] and [protein|19D76B80386F825109C5FB4A34881D5D20F366DB|comGC] (together with [protein|CED818CEF5B573A40F382157375E60C0B331F098|bdbD]) [Pubmed|11744713]
oxidative folding of [protein|1A6D90298D039FFFD977B2534952BA5E32B3530F|sunA] (together with [protein|12CE5AE0BD02C989E803480A1CE5A47D6192D751|bdbB])
Protein family
DsbB family (with [protein|12CE5AE0BD02C989E803480A1CE5A47D6192D751|bdbB], according to UniProt)
Structure
[AF|O32217]
[wiki|Localization]
cell membrane (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|CED818CEF5B573A40F382157375E60C0B331F098|bdbD]-[gene|A01637E1BFABA20A2923BA85A25CCD8A0D665F78|bdbC]
description
[Pubmed|11744713]
regulation
expressed early during sporulation in the mother cell ([protein|search|SigE]) [Pubmed|12480901]
regulatory mechanism
[protein|08CFA2C72931A75532D4289BC1D18A826DE9F9CA|comK]: activation, [Pubmed|11744713], in [regulon|protein:08CFA2C72931A75532D4289BC1D18A826DE9F9CA|comK regulon]
sigma factors
[protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE]: sigma factor, [Pubmed|12480901], in [regulon|protein:3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE regulon]
Biological materials
Mutant
GP4235 (Δ[gene|A01637E1BFABA20A2923BA85A25CCD8A0D665F78|bdbC]::''kan''), available in [wiki|Jörg Stülke]'s lab
GP4246 (Δ[gene|A01637E1BFABA20A2923BA85A25CCD8A0D665F78|bdbC]::''cat''), available in [wiki|Jörg Stülke]'s lab
MGNA-B603 (yvgU::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1602 NBRP B. subtilis, Japan]
BKE33470 ([gene|A01637E1BFABA20A2923BA85A25CCD8A0D665F78|bdbC]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE33470 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATTGTTACTTCCCTTTC, downstream forward: _UP4_TAACAAAAAAAGCGCCCGCG
BKK33470 ([gene|A01637E1BFABA20A2923BA85A25CCD8A0D665F78|bdbC]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK33470 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATTGTTACTTCCCTTTC, downstream forward: _UP4_TAACAAAAAAAGCGCCCGCG
References
Reviews
Original Publications
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Time of last update: 2024-12-22 00:18:53
Author of last update: MBenda