spoIIR
168
required for processing and compartmentalization of pro-[protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE]
locus
BSU_36970
Molecular weight
25.20 kDa
pI
4.74
function
control of [protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE] activation
product
morphological chekcpoint for [protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE] processing
essential
no
synonyms
spoIIR, ipc-27d, csfX
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG5822 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,794,676 3,795,350
The protein
Catalyzed reaction/ biological activity
interacts with and activates the pro-[protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE] protease [protein|221829E084DA78ACE1C2DFCEB6E59EDA534FF55D|spoIIGA] in the intermembrane space between the forespore and the mother cell [Pubmed|22111992]
Structure
[AF|P39151]
Modification
likely acylated on Thr-27 [Pubmed|22111992]
[wiki|Localization]
localizes initially to the forespore septal membrane (in a [protein|221829E084DA78ACE1C2DFCEB6E59EDA534FF55D|spoIIGA]-dependent manner), is then exported to the intermembrane space between the forespore and the mother cell [Pubmed|22111992]
Expression and Regulation
Operons
genes
[gene|9F338225E1286D530EAAAB504DEC8D5AFA06AC8D|spoIIR]
description
(according to [http://dbtbs.hgc.jp/COG/prom/spoIIR.html DBTBS]) null
regulation
expressed early during sporulation in the forespore ([protein|search|SigF]) [Pubmed|16497325,15699190]
sigma factors
[protein|CFF318EE6CACDEE763FBF96A2ABB46E944679AAA|sigF]: sigma factor, [Pubmed|16497325], in [regulon|protein:CFF318EE6CACDEE763FBF96A2ABB46E944679AAA|sigF regulon]
Biological materials
Mutant
BKE36970 ([gene|9F338225E1286D530EAAAB504DEC8D5AFA06AC8D|spoIIR]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE36970 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCGGTCCCCACCGTTCCT, downstream forward: _UP4_TAATCATCTGGTCTAAAAAT
BKK36970 ([gene|9F338225E1286D530EAAAB504DEC8D5AFA06AC8D|spoIIR]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK36970 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCGGTCCCCACCGTTCCT, downstream forward: _UP4_TAATCATCTGGTCTAAAAAT
References
Reviews
Original Publications
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Time of last update: 2024-12-17 15:49:50
Author of last update: Christoph.elfmann