bsuMA
168
DNA-3-methyladenine glycosidase II
locus
BSU_06060
Molecular weight
48.75 kDa
pI
7.66
function
BsuM DNA modification
product
DNA-3-methyladenine glycosidase
essential
yes
synonyms
ydiO
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0270 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
655,223 656,506
Phenotypes of a mutant
essential [Pubmed|12682299], mutation is only possible in a ''[gene|4BD4CFB10700907DF1BBF3C9CFACAF573588E85F|bsuRA]'', ''[gene|A8C606348C8C6FC3BB9786C06C9BFE9D3519A041|bsuRB]'', or ''[gene|D36B91B3C8EAFEB80A7395C62A50A5F80B8CC5C5|bsuRC]'' background (''i. e.'', in the absence of the BsuM DNA restriction system) [Pubmed|11751814]
The protein
Catalyzed reaction/ biological activity
2'-deoxycytidine in DNA + S-adenosyl-L-methionine --> 5-methyl-2'-deoxycytidine in DNA + H+ + S-adenosyl-L-homocysteine (according to UniProt)
Protein family
[wiki|Methyltransferase superfamily] (according to UniProt)
[wiki|class I-like SAM-binding methyltransferase superfamily] (according to UniProt)
[wiki|Domains]
SAM-dependent MTase C5-type domain (aa 84-427) (according to UniProt)
Structure
[PDB|3G7U] (from E. coli phage, 28% identity)
[AF|O34939]
Expression and Regulation
Operons
genes
[gene|9EE25F97B2C6240E31BA1D5EEE9DA2D7940C9637|bsuMA]-[gene|CEA337DD4C7DFC22247FDA7FA1E71356FB819C77|bsuMB]
description
[Pubmed|11751814]
regulation
induced by DNA damage ([protein|search|LexA]) [Pubmed|16267290]
regulatory mechanism
[protein|D267AF38B0CF107042326E9B8F3DD3C9C85840E4|lexA]: repression, [Pubmed|16267290], in [regulon|protein:D267AF38B0CF107042326E9B8F3DD3C9C85840E4|lexA regulon]
References
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Time of last update: 2024-12-21 15:45:07
Author of last update: Jstuelk